Regional-specific structural and functional changes of posterior cerebellar vermis across different stages of Parkinson's disease with gait dysfunction.
Liuzhenxiong Yu, Jinying Han, Xin Chen...
https://pubmed.ncbi.nlm.nih.gov/40651960Actively Recruiting
Phase Not Applicable
Age: 40Years - 85Years
All Genders
ID05192759
Effect of Theta-Burst Transcranial Magnetic Stimulation (TBS) for Freezing of Gait
Led by Anhui Medical University · Updated on 2025-11-19
40
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of Theta-burst Transcranial Magnetic Stimulation (TBS) on patients experiencing freezing of gait (FOG), a movement disorder symptom. This open-label clinical trial aims to assess both the treatment impact on symptoms and the underlying brain mechanisms involved in FOG. The study includes 40 patients diagnosed with FOG, with careful baseline assessments of motor and cognitive function. Participants receive daily active TBS treatment using the MagStim Rapid2 device for one week. Before and shortly after this treatment period, various clinical tests, neuropsychological assessments, and brain imaging techniques including MRI, EEG, and fNIRS are performed to measure changes. Follow-up assessments of clinical symptoms and cognition take place one month and two months after the last treatment session. During the study, patients complete tests such as the Freezing of Gait Questionnaire, Timed Up and Go test, and the Standing-Start 180° Turning Test to evaluate motor symptoms. Cognitive and mood evaluations include the Mini-Mental State Examination, Montreal Cognitive Assessment, and Hamilton depression/anxiety scales. Researchers monitor changes in these measures to understand treatment effects and safety over the study duration, which extends up to two months post-treatment.
CONDITIONS
Brief Title
Effect of Theta-Burst Transcranial Magnetic Stimulation (TBS) for Freezing of Gait
Who Can Participate
Age: 40Years - 85Years
All Genders
Eligibility Criteria
You may qualify if you...
- Diagnosis of freezing of gait by a movement disorder expert
- Score of item 3 on the Freezing of Gait questionnaire of 1 or higher
- Stable dose of any medication for at least 2 months
- Age 40 years or older
You will not qualify if you...
- History of addiction, psychiatric disorders, or neurological diseases other than Parkinson's disease
- Focal brain lesions visible on MRI scans
- Medication changes for Parkinson's disease during rTMS treatment
- Substance abuse history within the past 6 months
- Presence of nonremovable metal objects in or around the head
- Previous rTMS treatment
- History of seizures or family history of seizures in first-degree relatives
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Implementation
Duration - 1 week
Participants receive active transcranial magnetic stimulation (TMS) daily for 1 week.
Daily visits for 1 week
Follow-up
Duration - 2 months
Participants are assessed for clinical symptom and cognition changes after treatment.
Visits at 1 month and 2 months post-treatment
Trial Site Locations
Total: 1 location
1
Cognitive Neuropsychology Lab Anhui Medical University
Hefei, Anhui, China, 230032
Actively Recruiting
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Research Team
G
Gong-Jun JI, Ph.D.
J
Jinmei Sun, M.S.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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