Effect of Theta-Burst Transcranial Magnetic Stimulation TBS on Freezing of Gait in Adults Aged 40 to 85

What this Trial Is About

Researchers are evaluating the effects of Theta-burst Transcranial Magnetic Stimulation TBS on patients experiencing freezing of gait FOG, a movement disorder symptom. This open-label clinical trial aims to assess both the treatment impact on symptoms and the underlying brain mechanisms involved in FOG. The study includes 40 patients diagnosed with FOG, with careful baseline assessments of motor and cognitive function. Participants receive daily active TBS treatment using the MagStim Rapid2 device for one week. Before and shortly after this treatment period, various clinical tests, neuropsychological assessments, and brain imaging techniques including MRI, EEG, and fNIRS are performed to measure changes. Follow-up assessments of clinical symptoms and cognition take place one month and two months after the last treatment session. During the study, patients complete tests such as the Freezing of Gait Questionnaire, Timed Up and Go test, and the Standing-Start 180 Turning Test to evaluate motor symptoms. Cognitive and mood evaluations include the Mini-Mental State Examination, Montreal Cognitive Assessment, and Hamilton depressionanxiety scales. Researchers monitor changes in these measures to understand treatment effects and safety over the study duration, which extends up to two months post-treatment.

Effect of Theta-Burst Transcranial Magnetic Stimulation (TBS) for Freezing of Gait