Comparing Volatile Anesthesia and Total Intravenous Anesthesia on Brain Function and Recovery in Adults Undergoing Elective Brain Tumor Surgery

What this Trial Is About

Researchers are studying the effects of two different anesthesia methods on brain function and oxygen levels in patients undergoing planned brain tumor removal surgery. The study focuses on how these anesthetic agents influence brain stability, swelling, and inflammation during and after surgery, aiming to improve drug choices for brain tumor operations. It compares intravenous anesthesia with volatile inhaled agents in patients with supratentorial brain lesions. Participants will receive standard monitoring including heart rate, oxygen levels, blood pressure, and brain activity during surgery. Anesthesia will be maintained with either intravenous propofol or volatile agents sevoflurane or desflurane at specified concentrations and timing. Additional detailed blood gas and oxygenation measurements will be taken from arterial and jugular bulb blood samples at multiple time points during surgery. Brain relaxation and recovery will be assessed by medical staff, and blood samples will be collected to measure brain injury markers. Participants will undergo cognitive testing before surgery and one week after, along with evaluations of recovery quality and neurological function immediately after surgery and at hospital discharge. The study will track anesthesia emergence times, postoperative nausea risk, and overall brain oxygen saturation changes during surgery. Total participation includes preoperative assessment, intraoperative monitoring, and follow-up evaluations up to 24 hours post-surgery.

Effect of Volatile- Based Versus Total Intravenous Anesthesia on Brain Homeostasis and Neurocognitive Outcome