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Effect of Volatile-based Versus Total Intravenous Anesthesia on Cerebral Homeostasis and Neurocognitive Function in Patients Undergoing Elective Craniotomy for Brain Tumor Excision
Led by Georgia Tsaousi · Updated on 2025-10-01
84
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the effects of two different anesthesia methods on brain function and oxygen levels in patients undergoing planned brain tumor removal surgery. The study focuses on how these anesthetic agents influence brain stability, swelling, and inflammation during and after surgery, aiming to improve drug choices for brain tumor operations. It compares intravenous anesthesia with volatile inhaled agents in patients with supratentorial brain lesions. Participants will receive standard monitoring including heart rate, oxygen levels, blood pressure, and brain activity during surgery. Anesthesia will be maintained with either intravenous propofol or volatile agents sevoflurane or desflurane at specified concentrations and timing. Additional detailed blood gas and oxygenation measurements will be taken from arterial and jugular bulb blood samples at multiple time points during surgery. Brain relaxation and recovery will be assessed by medical staff, and blood samples will be collected to measure brain injury markers. Participants will undergo cognitive testing before surgery and one week after, along with evaluations of recovery quality and neurological function immediately after surgery and at hospital discharge. The study will track anesthesia emergence times, postoperative nausea risk, and overall brain oxygen saturation changes during surgery. Total participation includes preoperative assessment, intraoperative monitoring, and follow-up evaluations up to 24 hours post-surgery.
CONDITIONS
Brief Title
Effect of Volatile- Based Versus Total Intravenous Anesthesia on Brain Homeostasis and Neurocognitive Outcome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- ASA physical status 1 to 3
- Scheduled for elective or semi-elective craniotomy for brain tumor resection
- Signed informed consent
You will not qualify if you...
- History of craniotomy at the same site
- Morbid obesity
- Delirium before surgery
- Cognitive disturbances
- Preoperative heart rate below 45 beats/min or second or third degree AV block
- Treatment with a-methyldopa, clonidine, or other alpha-2 adrenergic agonists
- Pregnancy
- Liver or renal failure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for pre-anesthetic assessment including neurocognitive testing
Duration - Surgical procedure duration
Participants undergo elective craniotomy for brain tumor excision under anesthesia with either volatile agents (sevoflurane or desflurane) or total intravenous anesthesia (propofol). Various intraoperative monitoring and assessments are conducted during surgery.
1 surgical procedure visit (in-person) with continuous intraoperative monitoring and sampling at defined phases
Duration - Up to 1 week after surgery
Participants are monitored postoperatively for recovery, neurocognitive function, and brain injury biomarkers up to 24 hours after surgery and undergo neurocognitive testing 1 week after surgery.
Several visits: assessments at 24 hours postoperative, during hospital discharge, and 1 week post-surgery for neurocognitive testing
Trial Site Locations
Total: 2 locations
1
AHEPA University Hospital
Thessaloniki, Greece, 54645
Actively Recruiting
2
Aristotle University of Thessaloniki
Thessaloniki, Greece, 56224
Actively Recruiting
Research Team
G
Georgia Tsaousi, Professor
E
Eleni Chatsiou, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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