Actively Recruiting

Phase Not Applicable
Age: 65Years +
All Genders
ID07582913

Effects of Manual Versus AutoFlow Ventilation During Anesthesia Induction on Brain and Peripheral Oxygen Levels in Older Adults

Led by Ankara City Hospital Bilkent · Updated on 2026-05-15

106

Participants Needed

1

Research Sites

6 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are comparing manual ventilation and AutoFlow ventilation during the induction of general anesthesia to study their effects on brain and peripheral oxygen levels in older adults. This study focuses on patients aged 65 and older undergoing elective surgery, as age-related changes can affect breathing and blood flow, increasing the risk of low oxygen levels during anesthesia induction. The goal is to see if AutoFlow ventilation provides more stable oxygen delivery than manual ventilation in this population. Participants will receive general anesthesia with standard drugs followed by 2 minutes of mask ventilation using either manual ventilation by an anesthesiologist or AutoFlow ventilation delivered by a machine with preset settings including tidal volume, breathing rate, and pressure limits. Each patient is randomly assigned to one of these two groups to compare the effects on oxygen levels before and after intubation. During the study, researchers will continuously monitor oxygen saturation in the brain and peripheral tissues using special sensors, along with heart rate, blood pressure, and carbon dioxide levels at key times before, during, and after ventilation. This careful monitoring aims to measure how each ventilation method affects oxygen delivery and respiratory parameters. The study includes detailed data collection on patient characteristics and standard safety measurements throughout the procedure.

CONDITIONS

Brief Title

Manual Versus Autoflow Ventilation During Anesthesia Inductıon in Geriatric Patients

Who Can Participate

Age: 65Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients aged 65 years and older
  • Scheduled for elective surgery requiring endotracheal intubation under general anesthesia
  • American Society of Anesthesiologists (ASA) physical status I, II, or III
  • Willing to participate and able to provide written informed consent
Not Eligible

You will not qualify if you...

  • Severe heart failure or severe pulmonary disease
  • History or presence of brain tumors or cerebrovascular accidents (stroke)
  • Impaired cooperation or cognitive dysfunction such as dementia, delirium, or Alzheimer's disease
  • Known history or prediction of difficult airway
  • Allergy to materials used in the monitoring sensors

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Participants are assessed for eligibility including age, health status, and ability to consent before surgery.

Anesthesia Induction and Ventilation

Duration - Approximately 30 minutes on the day of surgery

Participants undergo standardized anesthesia induction followed by either manual or AutoFlow mechanical mask ventilation for 2 minutes prior to endotracheal intubation.

1 visit (in-person) during surgery

Trial Site Locations

Total: 1 location

1

Ankara Bilkent City Hospital Department of Anesthesiology and Reanimation

Ankara, Çankaya, Turkey (Türkiye), 06800

Actively Recruiting

Loading map...

Research Team

F

FATMA G KILIÇASLAN, Resident

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

Similar Trials

Aging, Geriatric Syndromes and Clonal Hematopoiesis

Geriatrics

Actively Recruiting

1 location

Breast Cancer Screening Decision Aid: A Survey-based Compari...

Mammography Screening

Actively Recruiting

1 location

Frequently Asked Questions

Have more questions? Get in touch with our team for quick support

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here

Published Research Related To This Trial

Effect of age on intraoperative cerebrovascular autoregulation and near-infrared spectroscopy-derived cerebral oxygenation.

C S Burkhart, A Rossi, S Dell-Kuster...

https://pubmed.ncbi.nlm.nih.gov/21835838

Effects of hyperventilation on cerebral oxygen saturation estimated using near-infrared spectroscopy: A randomised comparison between propofol and sevoflurane anaesthesia.

Tadahiko Ishiyama, Masakazu Kotoda, Nobumasa Asano...

https://pubmed.ncbi.nlm.nih.gov/27802250