Effect of age on intraoperative cerebrovascular autoregulation and near-infrared spectroscopy-derived cerebral oxygenation.
C S Burkhart, A Rossi, S Dell-Kuster...
https://pubmed.ncbi.nlm.nih.gov/21835838Actively Recruiting
Led by Ankara City Hospital Bilkent · Updated on 2026-05-15
106
Participants Needed
1
Research Sites
6 weeks
Total Duration
Researchers are comparing manual ventilation and AutoFlow ventilation during the induction of general anesthesia to study their effects on brain and peripheral oxygen levels in older adults. This study focuses on patients aged 65 and older undergoing elective surgery, as age-related changes can affect breathing and blood flow, increasing the risk of low oxygen levels during anesthesia induction. The goal is to see if AutoFlow ventilation provides more stable oxygen delivery than manual ventilation in this population. Participants will receive general anesthesia with standard drugs followed by 2 minutes of mask ventilation using either manual ventilation by an anesthesiologist or AutoFlow ventilation delivered by a machine with preset settings including tidal volume, breathing rate, and pressure limits. Each patient is randomly assigned to one of these two groups to compare the effects on oxygen levels before and after intubation. During the study, researchers will continuously monitor oxygen saturation in the brain and peripheral tissues using special sensors, along with heart rate, blood pressure, and carbon dioxide levels at key times before, during, and after ventilation. This careful monitoring aims to measure how each ventilation method affects oxygen delivery and respiratory parameters. The study includes detailed data collection on patient characteristics and standard safety measurements throughout the procedure.
CONDITIONS
Manual Versus Autoflow Ventilation During Anesthesia Inductıon in Geriatric Patients
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Participants are assessed for eligibility including age, health status, and ability to consent before surgery.
Duration - Approximately 30 minutes on the day of surgery
Participants undergo standardized anesthesia induction followed by either manual or AutoFlow mechanical mask ventilation for 2 minutes prior to endotracheal intubation.
1 visit (in-person) during surgery
Total: 1 location
1
Ankara Bilkent City Hospital Department of Anesthesiology and Reanimation
Ankara, Çankaya, Turkey (Türkiye), 06800
Actively Recruiting
F
FATMA G KILIÇASLAN, Resident
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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