Actively Recruiting
The Alterations of Brain Network Connectivity Under Sedation and Anesthesia in Patients With Supratentorial Glioma
Led by Beijing Tiantan Hospital · Updated on 2025-02-14
120
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how different anesthetics affect brain network connectivity and cognitive function in patients undergoing surgery for supratentorial glioma, a type of brain tumor. The study aims to understand how sedation and anesthesia influence brain activity and their link to postoperative delirium. This research uses advanced neuroimaging techniques to explore these effects in detail. Participants are divided into three groups based on the anesthetic used during surgery: dexmedetomidine, propofol, or remimazolam. Each participant receives sedation and maintenance using one of these drugs while undergoing surgery for their brain tumor. The study observes brain network changes before sedation, 30 minutes after sedation, and 30 minutes after surgery. Throughout the study, researchers collect data on brain network connectivity using neuroimaging, monitor electroencephalogram and regional cerebral oxygen saturation changes from admission to 10 minutes post-surgery, and assess postoperative delirium during the first five days after surgery. Participants are closely observed to understand how their brain function and cognition are affected by the anesthetics used during their procedure.
CONDITIONS
Brief Title
The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed as unilateral supratentorial glioma by MRI
- Scheduled for selective operation
- Age over 18 years old
- ASA physical status I-II
- Right handedness
You will not qualify if you...
- History of cerebrovascular disease, brain trauma, chemotherapy, radiotherapy, or psychotropic drug use
- History of intracranial surgery
- Drug and/or alcohol abuse
- History of dementia or mental illness
- Pregnant or lactating women
- Contraindications for MRI
- Severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome, or second-to-third degree atrioventricular block
- Severe hepatic or renal dysfunction
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Until surgery completion
Participants receive sedation with dexmedetomidine, propofol, or remimazolam during surgery.
1 surgery visit
Duration - 5 days
Participants are monitored for postoperative delirium and brain function changes after surgery.
Daily visits from Day 1 to Day 5 after surgery
Trial Site Locations
Total: 1 location
1
Beijing Tian Tan Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 100070
Actively Recruiting
Research Team
Y
Yuming Peng, MD,Ph.D
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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