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How Different Anesthetics Affect Brain Connectivity and Cognition in Adults With Supratentorial Glioma Undergoing Surgery
Led by Beijing Tiantan Hospital · Updated on 2025-02-14
120
Participants Needed
1
Research Sites
4 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are investigating how different anesthetics affect brain network connectivity and cognitive function in patients undergoing surgery for supratentorial glioma, a type of brain tumor. The study aims to understand how sedation and anesthesia influence brain activity and their link to postoperative delirium. This research uses advanced neuroimaging techniques to explore these effects in detail. Participants are divided into three groups based on the anesthetic used during surgery dexmedetomidine, propofol, or remimazolam. Each participant receives sedation and maintenance using one of these drugs while undergoing surgery for their brain tumor. The study observes brain network changes before sedation, 30 minutes after sedation, and 30 minutes after surgery. Throughout the study, researchers collect data on brain network connectivity using neuroimaging, monitor electroencephalogram and regional cerebral oxygen saturation changes from admission to 10 minutes post-surgery, and assess postoperative delirium during the first five days after surgery. Participants are closely observed to understand how their brain function and cognition are affected by the anesthetics used during their procedure.
CONDITIONS
Brief Title
The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma
Research Team
Y
Yuming Peng, MD,Ph.D
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