Actively Recruiting
Effects of Bariatric Surgery on Cardiovascular Risk Profile in Relation to Inflammatory Parameters: Endothelial Phenotyping and Analysis of the Cross-talk Between Adipose Tissue and Endothelium
Led by Maria Cecilia Hospital · Updated on 2026-05-08
85
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research investigates how obesity impacts heart and metabolic health, focusing on blood vessels and fat tissue functions. It aims to detect early signs of vascular problems and understand the communication between fat tissue and blood vessels. The study explores how bariatric surgery-induced weight loss may improve these functions and reduce cardiovascular risk over time. Participants undergo bariatric surgery, either mini-gastric bypass or sleeve gastrectomy. Before surgery, blood, urine, stool, and fat tissue samples are collected, along with a cardiology examination. These assessments continue at 6 and 12 months after surgery to monitor changes in vascular tissue, adipose tissue, inflammation, and related blood markers. During the study, participants attend follow-up visits for sample collection and health evaluations. Researchers measure vascular and adipose tissue changes from baseline to 12 months, focusing on blood vessel function and inflammatory substances. This ongoing monitoring aims to track recovery of endothelial health and overall cardiovascular risk after significant weight loss.
CONDITIONS
Brief Title
Effects of Bariatric Surgery on Cardiovascular Risk Profile in Relation to Inflammatory Parameters: Endothelial Phenotyping and Analysis of the Cross-talk Between Adipose Tissue and Endothelium
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years old or older
- Diagnosis of obesity with a Body Mass Index (BMI) of 30 kg/m² or higher
- Scheduled to undergo bariatric surgery via mini-gastric bypass or sleeve gastrectomy
- Able and willing to provide signed informed consent for personal data processing
- Willing to attend follow-up visits and complete all study assessments
You will not qualify if you...
- Active systemic inflammatory diseases such as chronic inflammatory bowel disease or chronic rheumatologic diseases
- Acute or chronic infections
- Severe anemia or coagulation disorders
- Moderate to severe chronic kidney disease
- Active malignancies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for eligibility assessment
Duration - Hospitalization period for surgery and immediate recovery
Participants undergo bariatric surgery, either mini-gastric bypass or sleeve gastrectomy, with immediate post-operative care.
1 hospitalization period for surgery
Duration - 12 months after surgery
Participants provide biological samples and undergo clinical assessments to evaluate cardiovascular and metabolic changes after surgery.
Follow-up visits at 6 and 12 months to collect blood, urine, stool, and adipose tissue samples and undergo cardiology examinations
Trial Site Locations
Total: 1 location
1
Maria Cecilia Hospital
Cotignola, Ravenna, Italy, 48033
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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