Impact of Bariatric Surgery on Heart and Blood Vessel Health and Inflammatory Factors in Adults with Obesity

What this Trial Is About

This research investigates how obesity impacts heart and metabolic health, focusing on blood vessels and fat tissue functions. It aims to detect early signs of vascular problems and understand the communication between fat tissue and blood vessels. The study explores how bariatric surgery-induced weight loss may improve these functions and reduce cardiovascular risk over time. Participants undergo bariatric surgery, either mini-gastric bypass or sleeve gastrectomy. Before surgery, blood, urine, stool, and fat tissue samples are collected, along with a cardiology examination. These assessments continue at 6 and 12 months after surgery to monitor changes in vascular tissue, adipose tissue, inflammation, and related blood markers. During the study, participants attend follow-up visits for sample collection and health evaluations. Researchers measure vascular and adipose tissue changes from baseline to 12 months, focusing on blood vessel function and inflammatory substances. This ongoing monitoring aims to track recovery of endothelial health and overall cardiovascular risk after significant weight loss.

Effects of Bariatric Surgery on Cardiovascular Risk Profile in Relation to Inflammatory Parameters: Endothelial Phenotyping and Analysis of the Cross-talk Between Adipose Tissue and Endothelium