Actively Recruiting
Comparison of Spinal and General Anesthesia on Systemic Inflammatory Response in Patients Undergoing Percutaneous Nephrolithotomy: Evaluation of SII, SIRI, AISI, NLR, and RDW
Led by Elazıg Fethi Sekin Sehir Hastanesi · Updated on 2026-04-22
90
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This observational study examines how spinal anesthesia compares with general anesthesia in affecting the body's systemic inflammatory response during percutaneous nephrolithotomy (PCNL), a kidney stone removal procedure. Researchers will analyze systemic inflammatory markers, including SII, SIRI, AISI, NLR, and RDW, calculated from routine blood tests taken before and after surgery to understand how anesthesia type might influence inflammation and related outcomes. Participants will receive either spinal anesthesia or general anesthesia as part of their routine clinical care during PCNL. The study does not add any extra treatments or interventions but observes the effects of these two anesthesia types as they are normally administered in clinical practice. During the study, blood samples will be collected within 6 hours before surgery and again between 6 to 24 hours after surgery to measure changes in inflammatory markers. Researchers will review these lab results to compare inflammation levels between the two anesthesia groups. The study aims to provide insights into how anesthesia choices may impact systemic inflammation around the time of surgery.
CONDITIONS
Brief Title
Effects of Spinal vs General Anesthesia on Systemic Inflammation in PCNL
Who Can Participate
Eligibility Criteria
You may qualify if you...
- American Society of Anesthesiologists (ASA) physical status class I-III
- Patients aged 18 years and older
You will not qualify if you...
- American Society of Anesthesiologists (ASA) physical status class IV or V
- Patients younger than 18 years
- Active infection or diagnosis of sepsis
- Malignancy
- Chronic inflammatory diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus)
- Use of immunosuppressive therapy
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Preoperative period (within 6 hours before surgery) to postoperative period (6 to 24 hours after surgery)
Participants who undergo routine percutaneous nephrolithotomy under spinal or general anesthesia are observed. Measurements of systemic inflammatory indices are collected before and after surgery.
1 baseline visit and 1 follow-up visit
Trial Site Locations
Total: 1 location
1
Fethi Sekin City Hospital
Elâzığ, Elaziğ, Turkey (Türkiye)
Actively Recruiting
Research Team
S
Sevim ŞENOL KARATAŞ, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here