High-Level Laser Therapy to Treat Oral Mucositis in Children Undergoing Bone Marrow Transplantation

What this Trial Is About

This trial investigates whether high-level laser therapy can help manage oral mucositis in children undergoing hematopoietic stem cell transplantation. The study aims to find out if this laser treatment is effective in reducing oral mucositis severity compared to basic oral care. The focus is on pediatric patients experiencing oral mucositis at grade II or higher on the WHO scale. Participants are randomly assigned to one of two groups. One group receives high-power laser therapy once daily for four days, using a laser with specific settings including a wavelength of 660 to 970 nm and power of 3.2 watts for 230 seconds in pulsed mode. The other group receives standard basic oral care, including mouth rinses with chlorhexidine and sodium bicarbonate three times daily. Treatments are administered during the oral mucositis phase. Throughout the study, participants will be evaluated at baseline, day 7, and day 11 for oral mucositis severity using the WHO scale and pain levels. The study tracks these outcomes to assess the impact of the treatments. Children will need to return for follow-up visits on days 7 and 11 after starting treatment. The study is sponsored by Ain Shams University and will run until December 2030.

Efficacy of High-Level Laser Therapy in Managing Oral Mucositis Among Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation