Renal Graft Functional Enhancement During Donor Anesthesia: Comparing Mannitol, Dopamine, and Hydration Treatments

What this Trial Is About

Renal transplantation is recognized as the preferred treatment for patients with end-stage renal disease. This research aims to compare the effects of three different treatments given during donor anesthesia to improve the function and blood flow of the transplanted kidney. The study focuses on assessing how Mannitol, Dopamine, and adequate hydration each impact kidney function after surgery. Participants will receive one of three treatments during anesthesia for kidney donation: a Mannitol infusion at 0.5 mg/kg over 15 minutes after anesthesia induction; a Dopamine infusion at 4 microg/kg/min from anesthesia induction until the renal artery is tied off; or adequate hydration via Ringer Acetate at 15 ml/kg/hr during the same period. These different approaches are being studied to find which best supports the transplanted kidney. During the study, researchers will monitor kidney function by measuring creatinine clearance seven days after surgery. Participants will be randomly assigned to one of the three treatment groups, and the study is single-blinded. The trial began in December 2018 and is expected to continue until December 2026. Adults aged 18 to 60 with end-stage renal disease who are living-kidney donors will be involved, with careful follow-up to compare outcomes across the treatment methods.

Enhancing Renal Graft Function During Donor Anesthesia