Actively Recruiting
Enhancing Treatment of Hepatitis C in Opioid Substitution Settings II (ETHOS II): A Partnership Project to Enhance Hepatitis C Care in Drug and Alcohol Clinics
Led by Kirby Institute · Updated on 2026-05-14
6000
Participants Needed
32
Research Sites
104 weeks
Total Duration
On this page
Sponsors
K
Kirby Institute
Lead Sponsor
N
National Health and Medical Research Council, Australia
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating ways to improve hepatitis C virus (HCV) care in drug treatment clinics and needle and syringe programs in New South Wales and across Australia. The ETHOS II Project aims to develop a framework to establish HCV screening and treatment programs in these settings nationally. This collaborative research involves several health organizations and focuses on people with a history of injecting drug use or those receiving opioid substitution therapy. The study includes an intervention called campaign days where participants receive hepatitis C screening, liver fibrosis assessments using fibroscans, and clinical assessments. Participants also complete surveys and may consent to link their data with population databases. A sub-study involves collecting blood samples from some participants to evaluate new diagnostic tests for chronic HCV infection. Additionally, interviews with policymakers, clinicians, and patients will explore barriers to HCV care, and an education program will be developed to improve workforce knowledge and care quality. Participants will be recruited from drug treatment clinics, general practitioners with high case loads, and needle and syringe programs. They will undergo hepatitis C testing, fibroscans, clinical assessments, and complete questionnaires during the campaign days. Researchers will track how many participants start anti-HCV treatment each year for up to three years. The study also includes follow-up through medical record reviews to monitor outcomes and improve treatment access and delivery.
CONDITIONS
Brief Title
ETHOS ENGAGE: Enhancing Treatment of Hepatitis C in Opioid Substitution Settings
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant has voluntarily signed the informed consent form
- 18 years of age or older
- History of injecting drug use
- Recent injecting drug use within the previous six months or currently receiving opioid substitution therapy
- These criteria do not apply for recruitment from residential rehabilitation centres
You will not qualify if you...
- None specified for exclusion in this study protocol
- No participants are excluded based on the provided criteria
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) during campaign days
Duration - Up to 3 years post enrolment
Participants who undergo routine care are observed through medical record review and surveys to assess hepatitis C treatment initiation and outcomes.
Follow-up through medical record review; no required in-person visits after campaign days
Trial Site Locations
Total: 32 locations
1
Canberra Alliance for Harm Minimisation & Advocacy (CAHMA)
Canberra, Australian Capital Territory, Australia, 2617
Actively Recruiting
2
Blacktown Methadone Management Clinic
Blacktown, New South Wales, Australia, 2148
Actively Recruiting
3
NSLHD Brookvale Community Health Centre
Brookvale, New South Wales, Australia, 2100
Actively Recruiting
4
Campbelltown Drug Health Services
Campbelltown, New South Wales, Australia, 2560
Actively Recruiting
5
HNELHD Drug and Alcohol Clinical Services Cessnock
Cessnock, New South Wales, Australia, 2325
Active, Not Recruiting
6
MNCLHD Coffs Harbour Alcohol and Other Drug Services
Coffs Harbour, New South Wales, Australia, 2450
Actively Recruiting
7
Rankin Court Treatment Centre
Darlinghurst, New South Wales, Australia, 2010
Actively Recruiting
8
NNSWLHD Grafton Alcohol and Other Drug Services
Grafton, New South Wales, Australia, 2460
Actively Recruiting
9
NBMLHD Drug & Alcohol Services Katoomba
Katoomba, New South Wales, Australia, 2780
Completed
10
MNCLHD Kempsey Alcohol and Other Drug Services
Kempsey, New South Wales, Australia, 2440
Actively Recruiting
11
NNSWLHD Lismore (Riverlands) Alcohol and Other Drug Services
Lismore, New South Wales, Australia, 2480
Actively Recruiting
12
NBMLHD Drug & Alcohol Services Lithgow
Lithgow, New South Wales, Australia, 2790
Completed
13
Liverpool Opioid Treatment Program
Liverpool, New South Wales, Australia, 2170
Actively Recruiting
14
WSLHD Mount Druitt Drug Health OST Clinic
Mount Druitt, New South Wales, Australia, 2770
Actively Recruiting
15
HNELHD Drug and Alcohol Clinical Services Newcastle
Newcastle, New South Wales, Australia, 2300
Actively Recruiting
16
Lawrence Avenue Methadone Program (LAMP)
Nowra, New South Wales, Australia, 2541
Actively Recruiting
17
WSLHD Fleet Street Drug Health OST Clinic
Parramatta, New South Wales, Australia, 2150
Actively Recruiting
18
MNCLHD Port Macquarie Alcohol and Other Drug Services
Port Macquarie, New South Wales, Australia, 2444
Actively Recruiting
19
NSLHD Herbert Street Clinic
Saint Leonards, New South Wales, Australia, 2065
Actively Recruiting
20
HNELHD Drug and Alcohol Clinical Services Tamworth
Tamworth, New South Wales, Australia, 2340
Active, Not Recruiting
21
HNELHD Drug and Alcohol Clinical Services Taree
Taree, New South Wales, Australia, 2430
Active, Not Recruiting
22
NNSWLHD Tweed Heads Alcohol and Other Drug Services
Tweed Heads, New South Wales, Australia, 2485
Actively Recruiting
23
The Orana Centre
Wollongong, New South Wales, Australia, 2500
Actively Recruiting
24
Biala City Community Health Centre
Brisbane, Queensland, Australia, 4034
Actively Recruiting
25
Youthlink
Cairns, Queensland, Australia, 4870
Actively Recruiting
26
Queensland Injectors Health Network (QuIHN)
Kirwan, Queensland, Australia, 4817
Completed
27
Townsville Sexual Health Services, North Ward Health Campus
Townsville, Queensland, Australia, 4810
Completed
28
Northern Drug and Alcohol Services South Australia (DASSA)
Elizabeth, South Australia, Australia, 5112
Actively Recruiting
29
Central Drug and Alcohol Services South Australia (DASSA)
Stepney, South Australia, Australia, 5069
Actively Recruiting
30
Next Step Fremantle
Fremantle, Western Australia, Australia, 6160
Actively Recruiting
31
Next Step Joondalup
Joondalup, Western Australia, Australia, 6027
Actively Recruiting
32
Next Step East Perth
Perth, Western Australia, Australia, 6004
Actively Recruiting
Research Team
D
David Silk, BSc
J
Jessie Payne
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
1
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