Evaluating a Diagnostic Algorithm to Guide Targeted Antibiotic Therapy in Adults with Infective Endocarditis

What this Trial Is About

Researchers are evaluating a diagnostic approach combining traditional culture-based methods with molecular techniques like PCR and sequencing to guide targeted antibiotic therapy for adults diagnosed with infective endocarditis. This randomized, open-label trial aims to assess whether using this combined diagnostic algorithm affects how often specific antibiotic treatments are prescribed within 14 days of diagnosis. The study is conducted across multiple centers with blinded assessment of outcomes. Participants are divided into two groups one receives standard diagnostic care plus access to molecular test results to help guide their antibiotic treatment, while the other group receives standard care alone without access to molecular results, which remain blinded to their physicians. Molecular samples are collected from all participants, but only the intervention groups doctors use these results for treatment decisions. During the study, participants will be monitored for the frequency of targeted antibiotic prescriptions within two weeks of diagnosis. Additional evaluations include complications requiring surgery, acute kidney injury, intensive care transfers by discharge around 14 days, and mortality within 30 days. The studys total duration includes initial diagnosis, treatment guidance, and short-term follow-up to track these outcomes.

Etiologic Diagnosis Algorithm in Infective Endocarditis