Actively Recruiting
Evaluation of Chronic Liver Disease Condition and Transplant Prognosis Assisted by Eye Biological Parameters
Led by Zhongshan Ophthalmic Center, Sun Yat-sen University · Updated on 2025-01-01
500
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
Z
Zhongshan Ophthalmic Center, Sun Yat-sen University
Lead Sponsor
F
First Affiliated Hospital, Sun Yat-Sen University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying the relationship between eye biological features and overall health conditions before and after liver transplantation. The goal is to see if eye measurements can help build a clinical prediction model to improve disease management around the time of liver transplant. This study is a bidirectional cohort design, using both past data and new patient information for model development and validation. The study includes different groups: patients registered for liver transplant from before surgery through follow-up after transplant, patients followed after liver transplantation, and healthy individuals without liver disease. Participants undergo various eye exams such as slit lamp photography, fundus photography, optical coherence tomography (OCT), and OCT angiography. They also receive general health tests including blood pressure, blood glucose, blood routine, coagulation, and liver function tests. Participants will be assessed from before surgery through postoperative follow-up, with data collected to improve the predictive model. Researchers will measure how well the model predicts liver transplant outcomes at 1 week and 1 year after surgery. The model's ability to assess liver disease severity after 1 year will also be evaluated. The study involves regular eye and health examinations, with participation lasting through these time points to monitor and analyze results.
CONDITIONS
Brief Title
Evaluation of Chronic Liver Disease Condition and Transplant Prognosis Assisted by Eye Biological Parameters
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age greater than or equal to 18 years old
- Late stage liver disease patients waiting for liver transplantation or with cirrhosis
- Ability to provide complete demographic information, liver function test results, liver pathology, and imaging results
- Ability to cooperate with eye examinations such as OCT and OCT angiography and obtain qualified data
- Voluntary agreement to follow the clinical trial protocol and sign informed consent
You will not qualify if you...
- History of other organ transplant surgeries
- History of eye laser treatment, medication injection, or eye surgery
- History of high myopia, glaucoma, or retinal and choroidal eye diseases
- History of major systemic diseases other than liver disease
- Inability to cooperate with eye examinations due to overall body or eye conditions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 year
Participants undergo various ophthalmic and general condition examinations to assess liver disease severity and eye biological parameters.
Multiple visits depending on participant group and timing of assessments
Duration - Up to 1 year after liver transplantation
Participants are monitored for prognosis prediction of liver transplantation and liver disease assessment through follow-up visits.
Follow-up visits at 1 week and 1 year after liver transplantation
Trial Site Locations
Total: 1 location
1
Zhongshan Ophthalmic Center, Sun Yat-sen University
Guangzhou, Guangdong, China, 510060
Actively Recruiting
Research Team
Z
Zizheng Cao, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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