Study of Dentin Graft and i-PRF With and Without Vitamin C for Preserving Bone After Tooth Extraction

What this Trial Is About

This research aims to evaluate changes in the width of the bone ridge after tooth extraction using autogenous demineralized dentin graft combined with injectable platelet-rich fibrin i-PRF, with or without added vitamin C. The study focuses on patients with non-restorable teeth who need socket preservation prior to dental implant placement. The goal is to see if adding vitamin C affects bone preservation by enhancing bone cell growth and soft tissue quality. Participants will undergo a flapless, minimally traumatic tooth extraction followed by filling the extraction socket with graft materials. One group receives dentin graft with i-PRF plus vitamin C, while the control group receives dentin graft with i-PRF alone. The graft mixture is prepared by cleaning and demineralizing extracted teeth, mixing with i-PRF derived from the participants blood, and adding vitamin C for the intervention group. The graft is secured with an absorbable gelatin sponge and sutures. Participants will have initial periodontal treatment and receive instructions for oral hygiene. Baseline and 3-month follow-up cone-beam CT scans will measure ridge width and height changes. Biopsies will be taken before implant placement for histological analysis. Follow-up visits occur at 3 days, 7 days, 2 weeks, and 3 months to assess healing, pain, and adverse events. The primary outcome is radiographic ridge width change at 3 months, with secondary outcomes including ridge height, new bone formation, and pain assessment.

Evaluation of Dentin Graft and I-PRF With and Without Vitamin C for Post-extraction Socket Preservation