Actively Recruiting
Evaluation of Fluid Responsiveness With Recruitment Maneuver After Sternotomy in Coronary Artery Bypass Surgery
Led by Ankara City Hospital Bilkent · Updated on 2024-07-16
45
Participants Needed
1
Research Sites
2 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying patients undergoing elective coronary artery bypass surgery to evaluate how well fluid responsiveness can be predicted after sternotomy using lung recruitment maneuvers and protective lung ventilation. The study focuses on assessing the reliability of dynamic indices such as pulse pressure variation (PPV) and stroke volume variation (SVV) in this setting to better predict fluid response. The goal is to improve management of fluid therapy in patients ventilated with 6 ml/kg of ideal body weight. During the study, patients will have their stroke volume index, cardiac index, and mean arterial pressure measured while lying in the lima position. Then, a lung opening maneuver applying 30 mmHg pressure for 30 seconds will be performed, followed by repeated measurements. After values return to normal, patients will receive balanced fluid at 3 ml/kg, and measurements will be recorded again to assess fluid responsiveness. Participants will be monitored from the start through four months to determine fluid responsiveness after surgery. The study involves careful observation of cardiovascular parameters before and after the lung recruitment maneuver and fluid administration. Researchers will gather data to understand the sensitivity and specificity of PPV and SVV changes in this context.
CONDITIONS
Brief Title
Evaluation of Fluid Responsiveness With Recruitment Maneuver After Sternotomy in Coronary Artery Bypass Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 80 years
- ASA physical status score of 2 or 3
- Scheduled for elective coronary artery bypass surgery under general anesthesia
- Agree to participate voluntarily
You will not qualify if you...
- Younger than 18 years or older than 80 years
- ASA score greater than 3
- Left ventricular ejection fraction below 40%
- Contraindications to anesthetic drugs
- Body mass index over 30
- Declined to participate in the study
- Right ventricular dysfunction
- Chronic obstructive pulmonary disease
- Bullous lung disease
- Moderate to severe pulmonary hypertension
- Severe kidney or liver disease
- Hemodynamic instability during the perioperative period
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Day of surgery
Participants undergo coronary artery bypass surgery during which researchers perform measurements to evaluate fluid responsiveness, including lung opening maneuvers and fluid administration.
1 visit (in-person)
Duration - Up to 4 months
Participants are monitored for changes in fluid responsiveness and recovery after surgery.
Trial Site Locations
Total: 1 location
1
Ankara Bilkent Şehir Hastanesi
Ankara, Turkey (Türkiye), 06800
Actively Recruiting
Research Team
M
meltem sakman yılmaz
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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