Understanding the Microbiomes Role in Esophageal and Stomach Leaks Using Microbial and Tissue Samples to Improve Patient Care

What this Trial Is About

Researchers are studying the role of the microbiome in foregut leaks, which are leaks in the esophagus or stomach. The study aims to understand the microbial composition involved in these leaks, how the virulence of the microbiome changes after leaks occur, and how the bodys response changes with different interventions. This information may help improve patient outcomes by identifying risks and guiding preventative measures. Participants will have samples of microbial fluid and tissue biopsy collected during medically necessary procedures. These samples will be analyzed to compare the microbiome composition and virulence within and between participants. The study will track healing times for leaks up to 24 weeks, the proportion of patients whose leaks close without further surgery, and the occurrence of complications within 30 days after surgery. During the study, patient demographics and risk factors for postoperative complications will be collected. Researchers will monitor healing progress and document leak resolution. The study involves assessing microbial samples at the time of surgery and following patients for up to 24 weeks to measure outcomes related to leak healing and complications.

Foregut Leaks-Role of Microbiome