Monitoring Blood Flow and Oxygen Levels During Controlled Blood Volume Reduction Using Lower Body Negative Pressure in Healthy Adults Aged 20 to 45

What this Trial Is About

This research focuses on healthy volunteers aged 20 to 45 to study changes in central and peripheral monitoring signals during controlled hypovolemia, which is a condition of decreased blood volume. The study aims to find the best site on the body to monitor hypovolemia using pulse oximeter waveforms from various locations including the finger, ear, forehead, and nose. It also evaluates other measurements such as blood pressure, cerebral oximetry, and peripheral venous pressure during gradual blood volume reduction. Participants will undergo gradual hypovolemia induced by lower body negative pressure LBNP, a method that simulates blood loss by applying suction to the lower body. During this process, continuous monitoring of pulse oximeter waveforms and other hemodynamic parameters will be conducted to observe changes. The study collects data to identify which peripheral site provides the most reliable monitoring for hypovolemia. Volunteers will be monitored closely throughout the procedure with various devices tracking cardiovascular and respiratory signals. The primary outcome is determining the most robust monitoring site for hypovolemia using pulse oximetry over a period of two years. Secondary measures include examining the connection between central heart function and respiratory changes seen in pulse oximeter signals during hypovolemia and fluid resuscitation. The total participation duration and follow-up are aligned with these measurement periods.

Hemodynamics Monitoring During Lower Body Negative Pressure (LBNP) Induced Controlled Hypovolemia