Studying Gut Microbiome Changes and Their Role in Pediatric Diseases and Growth from Birth Through Childhood

What this Trial Is About

Researchers are studying how changes in the gut microbiome relate to a variety of pediatric diseases and long-term health outcomes. This observational study focuses on understanding the connection between gut microbiome imbalances and diseases in children, while exploring how the microbiome recovers or worsens over time. The study aims to provide new insights into the gut-lung and gut-brain interactions during childhood. Fecal samples are collected regularly from newborns, including both preterm and full-term infants, through childhood. These samples undergo detailed analysis using genomic DNA extraction and 16S rRNA sequencing to identify microbial composition. Multiomics approaches, such as metabolomics, further explore gut microbiome dynamics. Laboratory models simulate the intestinal environment to study the microbiomes impact. Participants are followed from birth up to ten years old with regular monitoring of growth measures like height, weight, and head circumference at multiple timepoints. Developmental milestones are also tracked at key ages. The study observes the occurrence and frequency of infections such as enteritis, sepsis, and respiratory diseases. This long-term follow-up helps researchers understand microbiome changes and their health implications over childhood.

Human Microbiome Research and Development for Overcoming Pediatric Diseases