Genetics of Primary Graft Dysfunction Following Lung Transplantation

What this Trial Is About

Primary graft dysfunction (PGD) is a serious lung injury that can occur within days after lung transplant surgery. This condition affects up to 25% of lung transplant patients and is the leading cause of death after the procedure. Researchers are studying specific genetic factors in both lung donors and recipients that may increase the risk of developing PGD. Understanding these genetic markers could help predict who is more likely to experience this complication and potentially allow more transplants to be performed safely. The study involves individuals undergoing lung transplantation. Blood samples will be collected from lung donors and recipients before surgery, right after surgery, and 24 hours post-surgery. Researchers will monitor participants closely for 72 hours after surgery to check for symptoms of PGD, such as fluid buildup in the lungs and low blood oxygen levels. There are no additional study visits beyond this monitoring period. Participants will provide blood samples at specified times around their transplant surgery. During the first 72 hours after surgery, researchers will watch for signs of PGD to better understand its development in relation to genetic factors. This study does not require extra visits, focusing on the immediate post-surgery period. The main measurement is the presence or absence of primary graft dysfunction within 72 hours following the lung transplant.

Identifying Genetic Characteristics That Increase Risk of Primary Graft Dysfunction Following Lung Transplantation