Actively Recruiting
Imaging-based Assessment of Oral Biofilm and Gingival Health Using OTC Toothpastes and Mouthwashes
Led by University of California, Irvine · Updated on 2025-12-23
275
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to develop improved methods for measuring oral health by using photographs and imaging software. The study evaluates the effects of different over-the-counter toothpastes and mouthwashes on oral health, focusing on plaque levels, gum health, and saliva production. The goal is to find better ways to assess mouth health and determine if specific products can improve gum condition. Participants will be randomly assigned to use one of several toothpastes or mouthrinses. Toothpaste users will brush twice daily with a provided standard toothbrush and a specific dental gel, following a trained brushing technique. Mouthrinse users will continue their usual oral hygiene and rinse twice daily with a mouthwash after brushing. Study durations vary from 7 days to 6 months, with the initial period for developing imaging techniques and longer periods to validate them. During study visits, participants will have clinical assessments including plaque, gum inflammation, and bleeding recorded, as well as saliva production measured by expectorating into a cylinder. Photos of the mouth will be taken using an intraoral camera that does not capture the face. Visits last about 30 minutes, and the same investigator will evaluate participants at each visit. The study carefully avoids professional dental cleaning to maintain consistent data.
CONDITIONS
Brief Title
Imaging-based Assessment of Oral Biofilm and Gingival Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- At least 18 years of age or older
- In good general health
You will not qualify if you...
- History of allergy or intolerance of oral hygiene products such as toothpastes and mouthrinses
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 7 days or 1, 3, or 6 months
Participants use assigned over-the-counter toothpastes or mouthrinses twice daily for the study duration, following training on brushing techniques. They refrain from eating two hours before each visit. Plaque levels, gingival inflammation, sulcus bleeding, pocket depth, and saliva production are measured. Participants are photographed using an intraoral camera focusing on the mouth at each visit.
Visits at baseline and at Weeks 1, Month 1, Month 3, and Month 6 depending on study duration
Trial Site Locations
Total: 1 location
1
Beckman Laser Institute and Medical Clinic
Irvine, California, United States, 92617
Actively Recruiting
Research Team
D
Dr. Petra Wilder-Smith
N
Nicole Wakida, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
7