Effects of amine and stannous fluorides on plaque accumulation and gingival health in orthodontic patients treated with fixed appliances: a pilot study.
Melinda Madlena, Jolan Banoczy, Gergely Gotz...
https://pubmed.ncbi.nlm.nih.gov/22692271/Actively Recruiting
Led by University of California, Irvine · Updated on 2025-12-23
275
Participants Needed
1
Research Sites
N/A
Total Duration
This research aims to develop improved methods for measuring oral health by using photographs and imaging software. The study evaluates the effects of different over-the-counter toothpastes and mouthwashes on oral health, focusing on plaque levels, gum health, and saliva production. The goal is to find better ways to assess mouth health and determine if specific products can improve gum condition. Participants will be randomly assigned to use one of several toothpastes or mouthrinses. Toothpaste users will brush twice daily with a provided standard toothbrush and a specific dental gel, following a trained brushing technique. Mouthrinse users will continue their usual oral hygiene and rinse twice daily with a mouthwash after brushing. Study durations vary from 7 days to 6 months, with the initial period for developing imaging techniques and longer periods to validate them. During study visits, participants will have clinical assessments including plaque, gum inflammation, and bleeding recorded, as well as saliva production measured by expectorating into a cylinder. Photos of the mouth will be taken using an intraoral camera that does not capture the face. Visits last about 30 minutes, and the same investigator will evaluate participants at each visit. The study carefully avoids professional dental cleaning to maintain consistent data.
CONDITIONS
Imaging-based Assessment of Oral Biofilm and Gingival Health
D
Dr. Petra Wilder-Smith
N
Nicole Wakida, PhD
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University of California, Irvine
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Brushing with LivFresh Dental Gel | Brushing with OTC Toothpaste or Mouthrinse (LivFree, AIM, Crest Prohealth, Parodontax, Colgate Total, Lumineux or Listerine) |
|---|---|---|
| What it is | LivFresh Dental Gel is an over-the-counter oral care gel used for daily toothbrushing. | This group includes various commercially available over-the-counter toothpastes and mouthrinses such as LivFree, AIM, Crest Prohealth, Parodontax, Colgate Total, Lumineux, or Listerine. |
| Role in trial | Participants are randomly assigned to brush with LivFresh Dental Gel as their only dentifrice for the study period. | Participants are randomly assigned to brush with or rinse using one of the listed over-the-counter toothpastes or mouthwashes according to standard instructions. |
| Primary use | Daily removal of dental plaque and maintenance of gum health during routine brushing. | Standard dental hygiene to reduce plaque levels and help prevent gingivitis when used as directed. |
| How it is used or performed | Participants use the gel for regular toothbrushing, following instructions for twice-daily brushing throughout the trial period. | Participants brush teeth or use mouthrinse as assigned, twice daily or per product instructions for the trial duration. |
| Evidence status | LivFresh Dental Gel's effects on plaque and gum health in adults are under investigation in this randomized clinical trial, with outcomes to be measured over 1 week, 1 month, 3 months, and 6 months. | Manual toothbrushing with standard OTC dentifrices reduces plaque and gingivitis in adults, as supported by systematic reviews and clinical evidence. |
| Important limitations | Effectiveness compared to other OTC products is not yet established; actual patient outcomes will depend on adherence and real-world use. | Real-world effectiveness depends on regularity, duration, and technique of brushing or rinsing, which may vary among users. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 7 days or 1, 3, or 6 months
Participants use assigned over-the-counter toothpastes or mouthrinses twice daily for the study duration, following training on brushing techniques. They refrain from eating two hours before each visit. Plaque levels, gingival inflammation, sulcus bleeding, pocket depth, and saliva production are measured. Participants are photographed using an intraoral camera focusing on the mouth at each visit.
Visits at baseline and at Weeks 1, Month 1, Month 3, and Month 6 depending on study duration
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
7
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Lead Sponsor