Study of Dental Plaque and Oral Health in Adults with High Plaque and Varying Gingivitis Levels Using Sodium Monofluorophosphate Toothpaste

What this Trial Is About

Researchers are studying oral health by collecting and analyzing dental plaque and gingivitis measures in adults with different levels of plaque and gingival inflammation. This Phase 4 clinical trial aims to better understand the bacterial composition and oral health status in populations with high plaque but varying degrees of gingivitis. All participants will receive the same treatment consisting of brushing with a sodium monofluorophosphate toothpaste supplied by the study. The trial is a single-arm design enrolling up to 100 adults, with a target of 80 completing the study. Participants will use the provided toothbrush and toothpaste throughout the study period. Participants will undergo oral examinations and provide samples including gingival crevicular fluid, saliva, and plaque. They will also complete questionnaires about their oral health. Researchers will measure the relative abundance of specific bacteria, such as Streptococcus and Porphyromonas, over approximately 23 to 26 days. The study includes monitoring oral health changes and collecting data to assess plaque and gingivitis levels.

Clinical Study to Collect and Analyze Dental Plaque and Oral Health Measures in a Population With High Plaque/Low Gingivitis and High Plaque/High Gingivitis