Database and Biological Sample Collection for Patients with Minimal Glomerular Lesions and Primary Segmental and Focal Hyalinosis Nephrotic Syndrome in Children and Adults

What this Trial Is About

Idiopathic Nephrotic Syndrome INS is a kidney disease characterized by heavy protein loss in urine and low blood albumin levels. It includes two forms nephrotic syndrome with minimal glomerular lesions SNLGM and primary segmental and focal hyalinosis PHF. This research is an observational study aiming to understand immune system changes, podocyte cell damage, and genetic factors in INS. Currently, treatments are empirical with side effects. The study seeks to identify new treatment targets through biological sample collection and data analysis. Participants include children and adults diagnosed with either SNLGM or primary FSH. The study collects blood, tissue, and urine samples during planned follow-up visits. These samples will help analyze immune and podocyte changes and assess the effects of current treatments on new biomarkers. The study intends to create a biological collection and database to support future research and patentable discoveries. During the study, participants will provide biological samples as part of their regular follow-up care. Researchers will measure the number of biological samples collected over five years. The study involves signing informed consent and monitoring through planned visits, with no additional interventions beyond sample collection. Participant involvement spans several years to support understanding of INS progression and treatment impact, with safety and data collected under regular medical supervision.

From Immune System Damage to Podocyte Cell Damage: Prospective Database and Biological Collection of Patients (Children and Adults) With MGLS and HSFP