Actively Recruiting
Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia
Led by University of Missouri-Columbia · Updated on 2025-09-09
75
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to explore how early aging and menopause affect blood vessel responses to low oxygen levels, focusing on the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women. The study is conducted by the University of Missouri-Columbia and involves healthy female volunteers aged 18 to 70 years. It is designed as an early phase 1, randomized, single-masked clinical trial. Participants will be exposed to three experimental conditions: hypoxia (breathing low oxygen air through a mask), the cold pressor test (immersing the foot in ice water), and hypercapnia (breathing high carbon dioxide air through a mask). During the study, participants will receive one of three oral treatments: propranolol at 1 mg/kg, gemtesa at 75 mg, or a placebo pill, to study their effects on vascular responses. Throughout the trial, researchers will measure changes in forearm blood flow from baseline to five minutes after exposure. Participants will undergo these tests under controlled conditions to monitor cardiovascular responses. The study includes assessments related to aging, menopause, hypoxia, and vasodilation, with continuous safety monitoring. The total participation duration aligns with the study procedures and follow-up up to the planned end date in July 2026.
CONDITIONS
Brief Title
Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female assigned at birth
- Premenopausal, perimenopausal, or postmenopausal status
- Healthy weight with body mass index (BMI) between 18 and 30 kg/m2
You will not qualify if you...
- Male assigned at birth
- Pregnancy or breastfeeding
- Use of hormone replacement therapies
- History of hysterectomy
- Body mass index greater than 30 kg/m2
- Diagnosed sleep apnea
- Current smoking, nicotine, or drug use
- Nerve or neurologic diseases
- Cardiovascular, liver, kidney, or respiratory disease
- Blood pressure 140/90 mmHg or higher
- Diabetes or polycystic ovarian syndrome
- Communication barriers
- Use of prescription medications
- Malignant cancer
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of each treatment period varies according to crossover design
Participants receive oral propranolol, gemtesa, or placebo and undergo exposure to hypoxia, cold pressor test, and hypercapnia to assess vascular responses.
Multiple visits for each treatment and exposure period
Trial Site Locations
Total: 1 location
1
University of Missouri-Columbia
Columbia, Missouri, United States, 65211
Actively Recruiting
Research Team
J
Jacqueline Limberg
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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