Actively Recruiting
Impact of Personalised Cardiac Anaesthesia and Cerebral Autoregulation on Neurological Outcomes in Patients Undergoing Cardiac Surgery
Led by University Hospital, Basel, Switzerland · Updated on 2026-01-28
500
Participants Needed
4
Research Sites
235 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This international, multicentre prospective cohort study will assess whether perioperative duration and magnitude of mean arterial pressure (MAP) outside of an individual's cerebral autoregulation (CA) limits using near-infrared spectroscopy (NIRS) and transcranial Doppler (TCD) are associated with adverse neurological events. It is to investigate whether patients with a higher burden of cerebral haemodynamic insults have an increased incidence or poorer neurological outcomes. Associations between neurologic outcomes, neurobiomarkers and genetic tests will be explored.
CONDITIONS
Official Title
Impact of Personalised Cardiac Anaesthesia and Cerebral Autoregulation on Neurological Outcomes in Patients Undergoing Cardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Elective primary or reoperative coronary artery bypass graft and/or valvular and/or ascending aorta surgery requiring cardiopulmonary bypass
- Ability to understand and communicate in English, German, or French
- Ability to provide informed consent
- Age 65 years or older
You will not qualify if you...
- Surgery requiring moderate (28-31.9ºC) or deep (<28ºC) hypothermic circulatory arrest
- Heart and/or lung transplantation
- Urgent (within 24 hours) or emergency surgery
- Inability to follow procedures or insufficient knowledge in English, German, or French
- Inability to provide consent
- Cardiac surgery under minimal extracorporeal circulation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Clinic for Anaesthesia, Intermediate Care, Prehospital Emergency Medicine and Pain Therapy, University Hospital Basel
Basel, Switzerland, 4031
Actively Recruiting
2
Inselspital, Bern University Hospital
Bern, Switzerland, 3010
Actively Recruiting
3
Cambridge University Hospitals and Brain Physics Lab
Cambridge, United Kingdom, CB2 0QQ
Active, Not Recruiting
4
Royal Papworth Hospital, Department of Anaesthesia and Intensive Care
Cambridge, United Kingdom, CB2 0QQ
Actively Recruiting
Research Team
N
Nuno V. Gomes, MD
CONTACT
L
Luzius A. Steiner, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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