Actively Recruiting
Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation? A Randomized Controlled Trial
Led by Tanta University · Updated on 2025-09-12
45
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate how the timing of a single dose of dexmedetomidine before surgery affects the body's stress response during laryngoscopy and intubation. Maintaining stable heart and blood pressure levels during surgery is critical because it can improve surgical success and recovery. Dexmedetomidine is a drug that works on specific receptors to provide sedation, pain relief, and autonomic nervous system blockade, especially useful in patients with heart risks. Participants will be randomly assigned to one of three groups. One group receives 0.5 µg/kg dexmedetomidine over 10 minutes, 20 minutes before anesthesia induction, followed by saline 10 minutes before anesthesia. Another group receives saline 20 minutes before anesthesia, then dexmedetomidine 10 minutes before anesthesia. The control group receives only saline before anesthesia. The study uses a double-blind method to ensure unbiased results. During the surgery, researchers will monitor mean arterial pressure and heart rate up to 2 hours. They will also track the need for fentanyl during surgery and any adverse events up to 24 hours after surgery. Participants will be involved in the study from before anesthesia induction through the surgery and postoperative period to assess the effects of timing on stress response and safety.
CONDITIONS
Brief Title
Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation?
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age from 18 to 65 years
- Both sexes
- American Society of Anesthesiology (ASA) physical status I-II
You will not qualify if you...
- Severe cardiovascular problems
- Respiratory disorders
- Diabetes
- Hypertension
- Obesity
- Allergic reaction to study drugs
- Use of antihypertensive medications like b1-methyldopa, clonidine, or other b12-adrenergic agonists
- Use of medications that affect heart rate or blood pressure
- Pregnant women
- Currently breastfeeding women
- History of sleep apnea
- Scheduled for emergency procedures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 2 hours (duration of the surgery)
Participants receive a single dose of dexmedetomidine or saline before the induction of anesthesia to study the effects on stress response during laryngoscopy and intubation.
1 visit (in-person)
Duration - 24 hours postoperatively
Participants are monitored for adverse events and recovery for 24 hours after surgery.
Approximately 1 follow-up visit
Trial Site Locations
Total: 1 location
1
Tanta University
Tanta, El-Gharbia, Egypt, 31527
Actively Recruiting
Research Team
M
Mohammed S Elsharkawy, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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