Effect of Timing of a Single Dose of Dexmedetomidine Before Surgery on Stress Response During Laryngoscopy and Intubation

What this Trial Is About

This research aims to evaluate how the timing of a single dose of dexmedetomidine before surgery affects the bodys stress response during laryngoscopy and intubation. Maintaining stable heart and blood pressure levels during surgery is critical because it can improve surgical success and recovery. Dexmedetomidine is a drug that works on specific receptors to provide sedation, pain relief, and autonomic nervous system blockade, especially useful in patients with heart risks. Participants will be randomly assigned to one of three groups. One group receives 0.5 gkg dexmedetomidine over 10 minutes, 20 minutes before anesthesia induction, followed by saline 10 minutes before anesthesia. Another group receives saline 20 minutes before anesthesia, then dexmedetomidine 10 minutes before anesthesia. The control group receives only saline before anesthesia. The study uses a double-blind method to ensure unbiased results. During the surgery, researchers will monitor mean arterial pressure and heart rate up to 2 hours. They will also track the need for fentanyl during surgery and any adverse events up to 24 hours after surgery. Participants will be involved in the study from before anesthesia induction through the surgery and postoperative period to assess the effects of timing on stress response and safety.

Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation?