Actively Recruiting
Inflammatory Challenge and Fear
Led by University of California, San Francisco · Updated on 2025-12-15
288
Participants Needed
1
Research Sites
187 weeks
Total Duration
On this page
Sponsors
U
University of California, San Francisco
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to learn if short-term changes in the immune system alter how we process information and experience fear. The main questions it aims to answer are: Do people who receive typhoid vaccine respond differently than those who receive a placebo saline vaccine? Do people who receive typhoid vaccine experience changes in how they think and feel? Participants will: Attend four appointments at the San Francisco VA Health Care System; Receive typhoid vaccine or placebo at one of the visits; Have their physiological responding measured while listening to sounds; Complete questionnaires and psychological tests.
CONDITIONS
Official Title
Inflammatory Challenge and Fear
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18-60 years old
- Exposure to trauma
- Current PTSD or no history of PTSD
You will not qualify if you...
- Contraindications to typhoid vaccine
- Conditions associated with inflammation
- Pregnancy or plans to become pregnant in next three months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
San Francisco VA Health Care System
San Francisco, California, United States, 94121
Actively Recruiting
Research Team
A
Aoife O'Donovan, PhD
CONTACT
M
Michael Srouji, BA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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