Actively Recruiting
Innovative Multidisciplinary Strategies for Combating Severe Dengue
Led by Karolinska Institutet · Updated on 2025-02-10
1400
Participants Needed
2
Research Sites
251 weeks
Total Duration
On this page
Sponsors
K
Karolinska Institutet
Lead Sponsor
B
BIO BOX GUATEMALA ONG DE INVESTIGACIÓN, SERVICIOS Y DE MEDIO AMBIENTE
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to identify biomarkers and host factors associated with dengue severity in patients from dengue-endemic regions. The main question it aims to answer is: Can multi-omics approaches predict disease severity and identify key factors contributing to severe dengue infections? Participants will include individuals with dengue infection, and the study will analyze their blood samples using multi-omics techniques to uncover host immune responses, disease pathogenesis, and cellular pathway interactions. The study will also assess the role of primary and secondary infections, virus serotypes, and immunological factors in disease progression. Findings aim to support disease management, improve severity prediction, and identify potential therapeutic targets to prevent severe outcomes.
CONDITIONS
Official Title
Innovative Multidisciplinary Strategies for Combating Severe Dengue
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years and older
- Patients with dengue infection confirmed by anti-dengue IgM or NS1 ELISA
- For dengue without warning signs: fever plus at least two of the following symptoms: muscle or joint pain, nausea or vomiting, rashes, or low white blood cell count
- For dengue with warning signs: presence of dengue symptoms plus one or more of the following: abdominal pain with tenderness, persistent vomiting, fluid accumulation, mucosal bleeding, restlessness or lethargy, liver enlargement greater than 2 cm, increased hematocrit and rapid platelet count decrease
- For severe dengue: severe plasma leakage causing shock, severe bleeding evaluated by clinician, or severe organ involvement including liver enzymes AST or ALT ≥ 1000, impaired consciousness, or heart/other organ failure
- Healthy controls matched by age and sex who tested negative for dengue infection in the past three months
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Bio Box Guatemala Ong de Investigación, Servicios Y de Medio Ambiente
Guatemala City, Guatemala
Actively Recruiting
2
Manipal Academy of Higher Education (MAHE)
Mangalore, Karnataka, India, 576104
Actively Recruiting
Research Team
U
Ujjwal Neogi, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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