Actively Recruiting
Intestinal Immunity in Neurologic Disease
Led by Yale University · Updated on 2025-04-11
100
Participants Needed
1
Research Sites
265 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to ascertain the functional profiles of the immune cells within the gastrointestinal tract and to determine how these cells contribute to autoimmune and neurologic diseases.
CONDITIONS
Official Title
Intestinal Immunity in Neurologic Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 and up
- Recommended to undergo a screening colonoscopy (+/- upper endoscopy) as part of standard care, including healthy individuals and those with neurologic or autoimmune diseases
- Willing to undergo research colonoscopy (+/- upper endoscopy) for research purposes
You will not qualify if you...
- Currently pregnant; women of childbearing potential will have a pregnancy test before procedure
- Known or suspected chronic inflammatory gastrointestinal disease (e.g., inflammatory bowel disease)
- Known acute or chronic infections
- Use of systemic antibiotics (oral or IV) within 3 months before colonoscopy
- Use of systemic corticosteroids (prednisone 10 mg/day or higher for more than 5 days) within 2 weeks before colonoscopy
- Diagnosis or treatment for malignancy within the last 5 years
- Probiotic use within 2 weeks before procedure
- History of major gastrointestinal surgery (e.g., colon resection, gastric bypass)
- Bleeding disorder or use of anticoagulant medication
- Other medical conditions that increase biopsy risk as judged by investigator
- Allergy to MAC anesthesia or other drugs used during biospecimen collection procedure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Yale MS Clinic
North Haven, Connecticut, United States, 06473
Actively Recruiting
Research Team
C
Cynthia Marques
CONTACT
D
Dimitri Duvilaire
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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