Brand new norms for a good old test: Northern Italy normative study of MiniMental State Examination.
Giuseppe Foderaro, Valeria Isella, Andrea Mazzone...
https://pubmed.ncbi.nlm.nih.gov/34989910Actively Recruiting
Age: 60Years +
All Genders
Healthy Volunteers
ID06701630
Italian Adaptation and Validation of Functional and Behavioural Scales for Subjective Cognitive Decline, Mild Cognitive Impairment, and Mild Dementia
Led by Casa di Cura IGEA · Updated on 2025-02-13
390
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting an observational study to translate, adapt, and validate several functional and behavioral scales used for diagnosing neurodegenerative diseases in Italian, where formal versions are currently unavailable. The study focuses on scales assessing daily living activities and behavioral symptoms, including Katz's index, Lawton and Brody's scale, Everyday Cognition questionnaire (E-Cog), Neuropsychiatric Inventory Questionnaire (NPI-Q), and a modified Functional Activities Questionnaire (M-FAQ). The study also aims to evaluate the reliability and validity of these tools and to establish cut-off scores to distinguish between neurologically unimpaired elderly, subjective cognitive decline (SCD), mild cognitive impairment (MCI), and mild Alzheimer's disease (AD).
CONDITIONS
Brief Title
Italian Adaptation and Validation of Functional and Behavioural Scales for Subjective Cognitive Decline, Mild Cognitive Impairment and Mild Dementia.
Who Can Participate
Age: 60Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Age 60 years or older
- Availability of an informant or caregiver able to judge functional abilities
- Normal performance on the Mini Mental State Examination for neurologically unimpaired elderly participants
- Diagnosis consistent with Subjective Cognitive Decline for SCD group
- Diagnosis consistent with Mild Cognitive Impairment for MCI group
- Diagnosis consistent with Mild Major Neurocognitive Disorder according to DSM-5-TR for mild dementia group
You will not qualify if you...
- Refusal or inability to sign informed consent
- Presence of other neurological or psychiatric conditions that may explain cognitive difficulties for clinical groups
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - 1 day
Participants and their caregivers/informants provide demographic and clinical information, and undergo administration of functional rating scales and questionnaires to assess cognitive and behavioral status.
1 visit (in-person)
Long-term Monitoring
Duration - Up to the end of study completion (November 2026)
Participants are observed over time to validate the functional and behavioral scales and monitor cognitive and behavioral changes.
Assessments occur during study period as needed
Trial Site Locations
Total: 1 location
1
Casa di Cura Igea
Milan, Michigan, Italy
Actively Recruiting
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Research Team
S
Sabrina Guzzetti, Psychologist
L
Laura Veronelli, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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Published Research Related To This Trial
Guidelines for the process of cross-cultural adaptation of self-report measures.
D E Beaton, C Bombardier, F Guillemin...
https://pubmed.ncbi.nlm.nih.gov/11124735Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment.
B Winblad, K Palmer, M Kivipelto...
https://pubmed.ncbi.nlm.nih.gov/15324367Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory.
D I Kaufer, J L Cummings, P Ketchel...
https://pubmed.ncbi.nlm.nih.gov/11001602STUDIES OF ILLNESS IN THE AGED. THE INDEX OF ADL: A STANDARDIZED MEASURE OF BIOLOGICAL AND PSYCHOSOCIAL FUNCTION.
S KATZ, A B FORD, R W MOSKOWITZ...
https://pubmed.ncbi.nlm.nih.gov/14044222The Neuropsychiatric Inventory: assessing psychopathology in dementia patients.
J L Cummings
https://pubmed.ncbi.nlm.nih.gov/9153155Measurement of functional activities in older adults in the community.
R I Pfeffer, T T Kurosaki, C H Harrah...
https://pubmed.ncbi.nlm.nih.gov/7069156The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.
Guy M McKhann, David S Knopman, Howard Chertkow...
https://pubmed.ncbi.nlm.nih.gov/21514250A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease.
Frank Jessen, Rebecca E Amariglio, Martin van Boxtel...
https://pubmed.ncbi.nlm.nih.gov/24798886Cognitive Reserve Index questionnaire (CRIq): a new instrument for measuring cognitive reserve.
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https://pubmed.ncbi.nlm.nih.gov/21691143