Actively Recruiting
Latvian Early Atherosclerosis Registry
Led by Pauls Stradins Clinical University Hospital · Updated on 2024-05-01
100
Participants Needed
1
Research Sites
613 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Atherosclerosis and its complications are a global problem. There are several widely known and proven risk factors that promotes atherogenesis in the majority of patients. However, significant proportion of apparently healthy and young patients with cardiovascular disease but yet without recognized atherogenesis promoting risk factors can be observed in clinical practice. It highlights the need of new risk markers for early atherosclerosis diagnostics to prevent serious cardiovascular complications in these patients and in population in general. The interest in the negative impact of genetic variance, gene regulation on atherogenesis is growing. Therefore the purpose of this study is to analyze the impact of genetic variance and microRNA expression on early atherosclerosis development in the population of young, apparently healthy patients with coronary atherosclerosis. The primary hypothesis is that the group of patients with premature atherosclerosis have common genetic variations promoting early atherosclerosis development. The secondary hypothesis is that specific circulating microRNA expression (miR-126, miR-145 and miR-155) correlate with plaque lipid core by near infrared spectroscopy (NIRS) analysis.
CONDITIONS
Official Title
Latvian Early Atherosclerosis Registry
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent
- Early atherosclerosis defined as coronary atherosclerosis in men aged <55 years and women <65 years
- Coronary artery atherosclerosis with angiographically proven coronary vessel luminal stenosis ≥ 50% and ischaemia
- Coronary artery atherosclerosis with planned revascularization
- History of coronary artery revascularization (PTCA or coronary artery bypass surgery)
- Coronary vessel suitable for NIRS pullback
You will not qualify if you...
- Diabetes
- Total cholesterol ≥7 mmol/l and/or LDL ≥5 mmol/l
- Family hypercholesterolemia
- Positive family history of early cardiovascular disease (myocardial infarction, sudden cardiac death or cardiovascular disease of first degree relatives at young age - men <55 years, women <65 years)
- Malignant or resistant hypertension ≥10 years
- Body mass index ≥40 kg/m2
- 20 or more pack years of smoking
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Pauls Stradins Clinical University hospital
Riga, Latvia
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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