Study of Genetic Variations and microRNA in Early Coronary Atherosclerosis in Adults Undergoing Coronary Procedures

What this Trial Is About

This research aims to explore how genetic differences and microRNA levels may affect the early development of atherosclerosis in young, apparently healthy patients with coronary artery disease. The study focuses on individuals who have coronary atherosclerosis without the usual known risk factors, seeking new markers for early detection to help prevent serious heart complications. It is an observational study conducted by Pauls Stradins Clinical University Hospital in Latvia. Participants include patients undergoing coronary angiography or angioplasty who either lack clear atherosclerosis risk factors or have early coronary artery disease. Those without known risk factors will receive near-infrared spectroscopy NIRS imaging to analyze plaque lipid content. Blood samples will be collected to study microRNA expression miR-126, miR-145, miR-155 and genetic variations in key genes linked to cholesterol metabolism LDLR, APOB, PCSK9, LDLRAP1. During the study, researchers will record detailed medical histories, lifestyle factors, and medications. Blood tests will analyze cholesterol and other biochemical markers. Follow-up phone calls will occur at 6, 12, and 24 months to monitor changes in smoking status, medication use, and physical measurements. The primary outcome is genetic analysis at 12 months, with secondary outcomes including major cardiovascular events, intravascular imaging results, and any repeat procedures on coronary arteries.

Latvian Early Atherosclerosis Registry