Actively Recruiting
A Prospective Registry to Assess Atherosclerosis Risk Factors and Their Relationship With Coronary Plaque Properties and Genetic Variations in Patients With Early Atherosclerosis of Unclear Origin
Led by Pauls Stradins Clinical University Hospital · Updated on 2024-05-01
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to explore how genetic differences and microRNA levels may affect the early development of atherosclerosis in young, apparently healthy patients with coronary artery disease. The study focuses on individuals who have coronary atherosclerosis without the usual known risk factors, seeking new markers for early detection to help prevent serious heart complications. It is an observational study conducted by Pauls Stradins Clinical University Hospital in Latvia. Participants include patients undergoing coronary angiography or angioplasty who either lack clear atherosclerosis risk factors or have early coronary artery disease. Those without known risk factors will receive near-infrared spectroscopy (NIRS) imaging to analyze plaque lipid content. Blood samples will be collected to study microRNA expression (miR-126, miR-145, miR-155) and genetic variations in key genes linked to cholesterol metabolism (LDLR, APOB, PCSK9, LDLRAP1). During the study, researchers will record detailed medical histories, lifestyle factors, and medications. Blood tests will analyze cholesterol and other biochemical markers. Follow-up phone calls will occur at 6, 12, and 24 months to monitor changes in smoking status, medication use, and physical measurements. The primary outcome is genetic analysis at 12 months, with secondary outcomes including major cardiovascular events, intravascular imaging results, and any repeat procedures on coronary arteries.
CONDITIONS
Brief Title
Latvian Early Atherosclerosis Registry
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent
- Early atherosclerosis defined as coronary atherosclerosis in men aged <55 years and women <65 years
- Coronary artery atherosclerosis with angiographically proven coronary vessel luminal stenosis 8 50% and ischaemia
- Coronary artery atherosclerosis with planned revascularization
- History of coronary artery revascularization (PTCA or coronary artery bypass surgery)
- Coronary vessel suitable for NIRS pullback
You will not qualify if you...
- Diabetes
- Total cholesterol 87 mmol/l and/or LDL 85 mmol/l
- Family hypercholesterolemia
- Positive family history of early cardiovascular disease (myocardial infarction, sudden cardiac death or cardiovascular disease of first degree relatives at young age - men <55 years, women <65 years)
- Malignant or resistant hypertension 810 years
- Body mass index 840 kg/m 2 )
- 20 or more pack years of smoking
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - At time of recruitment
Participants undergo coronary angiography or percutaneous transluminal coronary angioplasty (PTCA) and intravascular near-infrared spectroscopy imaging to assess coronary plaque properties. Blood samples are collected to evaluate microRNA expression and perform genetic analysis.
1 visit (in-person)
Duration - 24 months
Participants are followed up by phone calls to collect additional information on smoking status, medication use, and anthropometric parameters to assess outcomes over time.
Phone calls at 6, 12, and 24 months
Trial Site Locations
Total: 1 location
1
Pauls Stradins Clinical University hospital
Riga, Latvia
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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