Asyut 1

Placenta accreta spectrum disorders PASD include abnormal implantation of the placenta into the uterine wall, such as placenta accreta, increta, and percreta. This condition is a significant obstetric concern, and current antenatal diagnostic methods do not provide complete certainty in diagnosis. This study aims to compare two common ultrasound methods, 3D ultrasound and 2D ultrasound with color Doppler, to assess their effectiveness in diagnosing placenta accreta spectrum. The study evaluates 3D ultrasound using placental volume measurements and vascular indices including vascularization index, flow index, and vascularization flow index. The 2D ultrasound assessment includes examining placental invasion criteria such as lacunar vascular flow, abnormal utero-placental interface, myometrial thinning, absence of retroplacental myometrium, interruptions at the utero-vesical interface, and lower uterine segment hypervascularity. These two diagnostic approaches are observed and compared during the study period. Participants will be pregnant women diagnosed with placenta previa and will undergo ultrasound examinations using both 3D and 2D methods. The primary outcome measure is the vascular index assessed at 1 month. Secondary outcomes include evaluation of 2D ultrasound parameters at the same time point. This observational study involves ultrasound imaging to monitor placental characteristics and blood flow, aiming to improve antenatal diagnosis of placenta accreta spectrum disorders.

Researchers are evaluating the clinical effectiveness and safety of a 577 nm diode laser to treat non-inflammatory acne, specifically acne comedones. Acne vulgaris commonly affects adolescents and young adults, often causing scarring and lowered self-esteem. This study aims to explore laser treatment as an alternative to traditional topical and oral medications, which may have side effects or compliance challenges. The laser targets sebaceous glands and bacteria involved in acne development to reduce lesions. In this study, all patients receive sessions of the 577 nm diode laser treatment on one side of their face while the other side serves as an untreated control for comparison. The treatment focuses on reducing comedonal lesions without other interventions applied to the control side. This approach allows direct evaluation of the lasers effect within the same individual over time. Participants will be assessed clinically before and after treatment, with the main outcome being the reduction in the number of comedones measured over three months. Researchers will monitor safety and treatment responses during this period. The entire study involves adults aged 18 to 40 years who have at least 10 comedonal lesions on both sides of the face. This setup helps gather detailed information about the lasers potential in managing non-inflammatory acne.

Researchers are studying the expression pattern of CD56, a marker found on natural killer cells and other immune cells, in patients with hematologic malignancies. These blood cancers arise from bone marrow or lymphatic system cells and include diverse diseases such as leukemia, lymphoma, and multiple myeloma. While CD56 overexpression has been linked to certain conditions like acute myeloid leukemia, this study aims to explore its pattern across various hematologic cancers. The study involves detecting CD56 expression using a diagnostic test called flow cytometry. Participants include newly diagnosed patients with hematologic malignancies and control healthy individuals. This observational study will compare CD56 expression between these groups without administering any treatment. During the study, participants will undergo the CD56 detection test and provide samples for analysis. Researchers will measure how CD56 is expressed in different blood cancers over one year. The study also monitors participant health and gathers data to better understand the role of CD56 in these diseases. The total duration involves initial testing and follow-up evaluations as needed.

Researchers are investigating ischemic stroke cases in patients who are on oral anticoagulants due to atrial fibrillation or other cardioembolic arrhythmias. This observational study, called ASPERA, aims to understand the characteristics of these stroke cases and to evaluate the short- and long-term outcomes of different strategies used to prevent recurrent strokes. The study includes both retrospective and prospective data collection from multiple centers worldwide, coordinated by the University of LAquila. The study has two parts ASPERA-R and ASPERA-P. ASPERA-R collects retrospective data over five years, focusing on baseline demographic, clinical, and neuroimaging features of ischemic strokes in patients on oral anticoagulants. ASPERA-P enrolls patients prospectively for two years with follow-up for five years to assess risks of stroke recurrence and safety events under different secondary prevention approaches, such as continuing or changing oral anticoagulation. Participants will have their data collected at several time points, including hospital admission, discharge, and follow-ups at 90 days, 1 year, and 5 years after stroke. Assessments include clinical evaluations, neuroimaging exams, and monitoring for stroke recurrence, bleeding events, heart attacks, and mortality. The study tracks outcomes to better understand risks and to identify features linked to stroke recurrence and safety events, with total participation lasting up to seven years for prospective patients.

Researchers are investigating the albumin bilirubin index to predict the risk of recurrent bleeding within three months after endoscopic treatment in patients with cirrhosis and esophagogastric variceal bleeding EGVB. The study aims to clarify how well this index can forecast bleeding outcomes, which may help guide future care for affected patients. The research is observational and sponsored by Assiut University. Participants will be observed following their endoscopic treatment without receiving additional experimental interventions. The study focuses on monitoring patients over time to evaluate the relationship between their albumin bilirubin index levels and bleeding recurrence. No specific treatments or procedures beyond standard care are assigned by the study. During the study, participants health and bleeding status will be regularly assessed to track the prevalence of variceal bleeding in those with a high albumin bilirubin index over six months. Data collection will include clinical evaluations and laboratory tests as part of routine care. The study duration and follow-up are structured to gather meaningful information on this predictive markers value.

Researchers are studying the effectiveness of different nerve blocks and intrathecal morphine for managing pain after cesarean section surgery. The study aims to compare how long these methods provide pain relief after surgery in women aged 18 to 40 years who have elective cesarean deliveries. This randomized trial is sponsored by Assiut University and focuses on postoperative pain control. Participants are assigned to one of three groups one group receives intrathecal morphine with standard spinal anesthesia the second group receives the same spinal anesthesia plus a bilateral Quadratus Lumborum nerve block with bupivacaine and dexamethasone the third group receives spinal anesthesia plus a bilateral Erector Spinae nerve block with the same drugs. All treatments are given during cesarean section surgery. During the study, participants will be monitored to measure how long the pain relief lasts until the first request for additional pain medication within 24 hours after surgery. The trial follows participants through this period to assess and compare the duration of analgesia provided by each method. Safety and pain control will be closely observed throughout the study.

Researchers are investigating whether arterial stiffness, measured by Pulse Wave Velocity, can independently predict acute kidney injury in patients with sepsis. The study also compares Pulse Wave Velocity with shear wave ultrasound elastography as different ways to evaluate arterial stiffness in predicting this kidney complication. The research involves collecting detailed patient information including age, sex, medical history, and sepsis source. Clinical data like vital signs, fluid status, and lab tests such as blood counts and kidney function are recorded. Measurements of arterial stiffness using Pulse Wave Velocity and shear wave elastography are taken within the first 24 hours of ICU admission. Renal resistive index is also assessed using Doppler ultrasound. All assessments are done by trained examiners. Participants will be monitored through clinical exams, blood tests, ECG, echocardiography, and sepsis evaluations. Researchers will analyze these data to see how arterial stiffness relates to kidney injury in sepsis over a two-year period. The study tracks organ function scores and collects comprehensive cardiovascular and kidney-related measurements to understand this relationship better.

Researchers are evaluating the pain relief effects of two ultrasound-guided regional anesthesia techniques, the transversus thoracic muscle plane block TTPB and the pecto-intercostal fascial block PIFB, in patients undergoing open cardiac surgery. This study focuses on managing the significant pain that occurs after sternotomy, which is a common and painful part of cardiac surgery, especially within the first 24 hours post-operation. Participants will be randomly assigned to one of three groups receiving PIFB, receiving TTPB, or receiving a sham procedure with superficial saline injection. Both PIFB and TTPB blocks are performed intraoperatively using bupivacaine combined with dexamethasone to target nerves supplying the anterior chest wall. The sham group receives superficial needle punctures without active anesthetic injection. During the study, participants analgesic requirements, pain levels, need for rescue pain medication, nausea and vomiting, time to extubation, ICU stay duration, delirium assessment, patient satisfaction, and any complications will be monitored primarily within 24 hours and up to 7 days after surgery. The total participation lasts up to the completion of the postoperative assessments, with the primary outcomes focused on pain control and recovery measures after cardiac surgery.

Researchers are studying the effects of preoperative intravenous and nebulized tranexamic acid on patients undergoing functional endoscopic sinus surgery FESS, a common treatment for conditions affecting the nasal cavity and paranasal sinuses. The study aims to assess how these treatments impact surgical field visibility using the Modena Bleeding Score, blood loss, anesthetic use, and patient hemodynamics. It also monitors potential postoperative complications such as nausea, vomiting, visual disturbances, seizures, and clotting events. Participants will receive either intravenous or nebulized tranexamic acid before surgery to compare their effects on controlling bleeding during FESS. Tranexamic acid works by inhibiting fibrinolysis, which helps reduce bleeding. The study evaluates the two methods of administration to determine which better improves the surgical experience for both surgeons and patients. Throughout the study, participants vital signs like blood pressure, respiratory rate, temperature, pulse, oxygen saturation, and end-tidal CO2 will be monitored. Researchers will measure intraoperative bleeding by blood volume collected and gauze count, track anesthetic consumption including extra doses of fentanyl, propofol, and sevoflurane, and observe any postoperative complications. The trial includes regular assessments to evaluate safety and effectiveness, with participation lasting through the surgical procedure and immediate recovery period.

Fibromyalgia FM is a common rheumatic condition characterized by chronic pain, fatigue, cognitive problems, and difficulty with daily function. This trial investigates differences in FM symptoms between men and women, especially following the 2016 American College of Rheumatology criteria. The disease is more frequent and severe in women, and neurological symptoms like tinnitus, vertigo, and dizziness are often reported, potentially linked to vestibular system effects. Participants will undergo audiovestibular assessments to explore hearing sensitivity and balance issues related to FM. This observational study does not involve treatment but focuses on diagnostic testing to better understand the impact of FM on the vestibular system and whether dizziness is caused by FM itself or other factors like autonomic dysfunction. During the study, participants aged 15 to 50 diagnosed with FM will have their hearing and balance evaluated over a period of up to two years. Researchers will monitor hearing sensitivity as the primary outcome and collect data on neurological symptoms. The study includes regular assessments to track these measures and aims to improve understanding of FMs effects on the ear and balance systems.