Ismailia 2

Researchers are evaluating whether giving magnesium sulphate before early birth can reduce the chance of cerebral palsy in babies born to women at high risk of preterm delivery. This Phase 3 randomized clinical trial focuses on pregnant women between 32 and 35 weeks of gestation who are likely to give birth within 24 hours. The study also aims to assess the safety of magnesium sulphate for both mothers and their newborns, comparing it with a placebo treatment. Participants will be randomly assigned to receive either intravenous magnesium sulphate or a placebo solution. The magnesium sulphate treatment involves a loading dose followed by a continuous infusion for up to 24 hours or until delivery, while the placebo group receives an equal volume of isotonic sodium chloride. Both groups will have clinical monitoring during the infusion to watch for any side effects. The study maintains blinding so that neither participants nor outcome assessors know which treatment was given. Throughout the study, mothers will be monitored during treatment, and newborns will receive standard care along with any needed cranial ultrasound screening. After discharge, infants will be followed up with neurodevelopmental assessments at corrected age to check for cerebral palsy. The main outcome is the combined rate of death or cerebral palsy by 6 months corrected age, helping determine if antenatal magnesium sulphate offers neuroprotection without significant adverse effects.

Researchers are investigating the combined effect of sensory-motor integration on balance improvement and pain reduction in women with postmenopausal peripheral neuropathy, specifically sensory-motor axonal neuropathy. This study focuses on postmenopausal women aged 45 to 55 years who have type II diabetes mellitus and experience numbness in their upper and lower limbs for over four months. Participants will be divided into groups receiving either sensory-motor integration therapy, which includes pelvic rocking training and strengthening exercises, or traditional conventional exercises. These interventions aim to evaluate their impact on improving balance and reducing pain over a six-week period. During the study, participants will be monitored and assessed for changes in pain intensity and balance after six weeks of treatment. Researchers will use these measurements to understand how the therapies affect sensory-motor integration and neuropathy symptoms in the target population.

Dental caries is a dynamic process that can be reversible or irreversible depending on factors in the mouth. If untreated, it can cause injury, inflammation, and death of the tooth pulp. Melatonin may influence tooth cell growth similarly to how it affects bone cells, making it of interest for dental treatments. This research aims to compare the effects of melatonin and mineral trioxide aggregate (MTA) on vital pulp therapy in young permanent first molars in children aged 6 to 8 years. The study will involve 45 young permanent first molars divided into three groups: one treated with MTA, one with melatonin, and one with both MTA and melatonin after an apexogenesis procedure. After placing the materials on the dental pulp, a conventional glass ionomer cement will be used as a permanent restoration. Immediate postoperative digital X-rays will be taken, followed by scheduled follow-ups at 1, 3, 6, 9, and 12 months to assess healing. Participants will be evaluated clinically and through radiographic imaging at each follow-up to monitor pulp response and tooth healing. Assessments include pain scales, pulp vitality, and radiographic measurements using specialized software. The study measures outcomes immediately after treatment and at multiple time points up to 12 months to understand the effectiveness and healing progress of the different treatments.

Researchers are evaluating and comparing two intravenous insulin infusion protocols to improve blood sugar control in critically ill adult patients with diabetes admitted to the intensive care unit (ICU) at Suez Canal University (SCU) hospitals. The study aims to determine whether the SCU protocol or the National Health Service (NHS) protocol from the UK better achieves target blood glucose levels in this patient group. This comparison focuses on enhancing glycemic control efficacy during critical illness. Participants will be randomly assigned to either the SCU protocol group or the NHS protocol group for intravenous insulin infusion. Both groups receive insulin via a variable rate intravenous infusion of regular insulin mixed with saline, adjusted according to the assigned protocol. Two nurses will prepare and verify the insulin infusion, which is stopped if blood glucose drops below 80 mg/dl, with repeat measurements after one hour. Potassium levels will be closely monitored and managed with specific replacement strategies depending on serum potassium concentrations. Throughout the study, demographic and clinical data including severity scores and medical history will be collected at baseline. Routine blood tests and other laboratory investigations will be conducted regularly, alongside monitoring nutrition status, mechanical ventilation days, and complications like diabetic ketoacidosis or hypoglycemia. Researchers will measure the time needed to reach target blood glucose levels (80-180 mg/dl) within 28 days. The study also records ICU and hospital discharge dates and patient outcomes such as discharge or death.

Researchers are evaluating the efficiency of direct 3D printed aligners in moving the crowns of upper and lower front teeth in adults with spacing between teeth. The study compares the actual tooth movements achieved during treatment with the predicted movements planned before treatment. It involves adult patients aged 18 to 45 years with specific dental conditions including spacing and certain types of malocclusion. The study involves 23 patients who will receive direct 3D printed aligners after intraoral scans of their upper and lower teeth. Patients will use these aligners, changing each set every 10 days according to instructions, with aligners warmed before use to help fit and comfort. At the end of treatment, another intraoral scan will be taken to capture the actual dental changes. The predicted and actual tooth movements will be digitally compared using 3D models and software. Throughout the study, patients will undergo intraoral scanning before and after treatment. The digital models will be superimposed to measure the crown movements of the incisors in millimeters. Data will be collected and analyzed statistically to assess the aligners' performance over 9 to 12 months. This includes careful monitoring of tooth positions and treatment progress to evaluate the effectiveness of the 3D printed aligners in correcting spacing issues.

Researchers are evaluating the effects of abdominal massage compared to visceral manipulation on constipation and quality of life in adults aged 20 to 40 years with chronic idiopathic constipation. This condition involves difficult, infrequent, or incomplete bowel movements and can significantly impact daily life and healthcare costs. The study focuses on adults diagnosed according to Rome IV criteria with symptoms lasting 6 to 12 months. Participants will receive either abdominal massage or visceral manipulation three times per week, with each session lasting about 20 to 25 minutes over six weeks. In addition, all participants will be given instructions on daily habits, diet, toilet use, physical activity, and behavioral therapy to support effective defecation and lifestyle improvements. Throughout the study, researchers will monitor constipation severity, bowel function, and quality of life using several questionnaires and assessment scales at the six-week mark. These include the Constipation Severity Instrument, Constipation Assessment Scale, Patient Assessment of Constipation-Quality of Life Questionnaire, and Bowel Function Index. The study aims to understand how these treatments affect constipation status and overall well-being.

Researchers are investigating how local corticosteroids and maintaining apical patency affect pain after root canal treatment in patients with acute irreversible pulpitis in molar teeth. This randomized clinical trial aims to determine how effective these approaches are in reducing post-preparation pain and neuropeptides release. Participants will record their pain levels using a visual analogue scale during the study. The study compares two main interventions: an injection of 0.7 ml dexamethasone given laterally to the involved tooth after anesthesia and no corticosteroid injection. Both groups receive root canal treatment, with or without maintaining apical patency, to evaluate differences in pain reduction. The trial includes patients aged 21 to 60 years with symptomatic irreversible pulpitis and normal periapical and periodontal conditions. Participants will be monitored for post-operative pain at 6, 12, 24, 48, 72 hours, and 7 days after treatment. Inflammatory markers will be measured before treatment, and again after 3 and 7 days. The study excludes those with facial or oral paresthesia, pregnancy, breastfeeding, unrestorable teeth, periodontal disease, crowns on the involved tooth, long-term corticosteroid use, or other specific dental conditions. This careful monitoring helps assess safety and treatment effects over one week following the procedure.

Researchers are investigating the combined effect of Extracorporeal Shock Wave Therapy (ESWT) and core stability exercises (CSEs) for treating chronic non-specific low back pain in female Jordanian university students aged 16 to 18 years. This condition is common and often related to muscle weakness, poor posture, and soft tissue problems. ESWT and CSEs are non-invasive treatments that may work well together to reduce pain and improve function. The study evaluates the impact of ESWT delivered as high-energy acoustic waves to promote tissue healing and reduce pain, alongside core exercises that strengthen deep spinal muscles to improve stability and posture. Participants will receive shock wave therapy combined with exercises focusing on core muscles, aiming to quickly relieve pain and improve long-term spinal function. Participants will be monitored for back pain improvement over 12 weeks. Assessments include pain levels and physical function. The study specifically enrolls females with chronic back pain lasting more than three months, with BMI between 20 and 22, and who have certain teaching hour schedules. Safety and effectiveness will be observed throughout the trial period.

Researchers are evaluating the effectiveness of combining virtual reality with plyometric workouts to address abdominal obesity in adolescent females. The study aims to compare exercise capacity and health parameters between two groups of teenage females with abdominal obesity, aged 13 to 18 years. One hundred adolescent females will be randomly divided into two groups of 50 participants each. Group A will use an immersive virtual reality system combined with plyometric exercises, while Group B will perform treadmill aerobic workouts for 10 minutes along with plyometric exercises. The intervention will last for three months. Before starting the program, researchers will measure waist circumference, waist-hip ratio, body mass index (BMI), and perform pulmonary function tests including inspiratory reserve volume, expiratory reserve volume, tidal volume, inspiratory capacity, and vital capacity. These measurements will be repeated after 12 weeks of treatment to assess changes in abdominal obesity and lung function.

Researchers are studying a procedure called maxillary sinus floor augmentation in adults aged 18 to 60 who need dental implants in the upper jaw where bone height is insufficient. The study compares two methods to support the sinus membrane during the procedure: one uses a titanium mesh fixed with bone screws, and the other uses stainless steel screws or pins to keep the membrane elevated and stabilize the blood clot. Both groups receive platelet rich fibrin (PRF) placed at the site to support healing. The study divides participants into two groups. Group I will have the sinus membrane tented with titanium mesh secured by bone screws. Group II will have stainless steel screws or pins placed bucco-palatally to maintain membrane elevation and clot stability. The treatments involve surgical elevation of the Schneiderian membrane to allow bone growth for implant placement. Participants will be monitored over six months, during which researchers will evaluate bone quality through histological examination and measure bone gain using radiographic imaging. The study focuses on clinical, radiographic, and tissue-level assessments to understand how well each method supports bone growth and healing after the sinus lift procedure.