Ismailia 2

Researchers are evaluating the effectiveness of different palatal dressing materials for healing wounds after free gingival graft surgery. This randomized controlled trial will include 30 healthy patients with mucogingival defects who need free gingival grafts. The study aims to find out which dressing provides better postoperative comfort and improves healing at the donor site. Participants will be randomly divided into three groups of 10. One group will receive a gelatin sponge with flowable composite as a control dressing. The second group will have hyaluronic acid gel applied and then covered with a gelatin sponge and flowable composite. The third group will receive active oxygen gel with the same covering materials. The grafts will be harvested using a standard surgical technique, and dressings will be applied to the donor site accordingly. Patients will be given pain medication and mouth rinse as standard postoperative care. Participants will be monitored through follow-up visits at 1, 2, and 4 weeks after surgery. Pain levels, analgesic use, wound healing progress using the Landry healing index, complete wound epithelialization via hydrogen peroxide test, wound size changes, and any complications will be assessed. These evaluations will help determine the healing quality and comfort associated with each dressing type over the four-week period.

Researchers are evaluating whether giving magnesium sulphate to pregnant women at high risk of preterm birth can reduce the chance of cerebral palsy in their infants. This trial focuses on women between 32 and 35 weeks of pregnancy who are expected to deliver within 24 hours. The study also aims to assess the safety of magnesium sulphate for both mothers and newborns by comparing it to a placebo. Participants will be randomly assigned to receive either intravenous magnesium sulphate or a placebo. The magnesium sulphate is given as a 4 gram loading dose over 20 minutes, followed by a maintenance infusion of 1 gram per hour until delivery or for up to 24 hours. The placebo group receives an intravenous sodium chloride solution following the same schedule. Both groups will receive standard obstetric and neonatal care throughout the study. During the study, mothers will be monitored for side effects while receiving the infusion. Newborns will have routine assessments and cranial ultrasound screenings when needed. After discharge, infants will be followed up with neurodevelopmental evaluations to check for cerebral palsy. The main outcome measured is the combined rate of death or cerebral palsy at 6 months corrected age. The study will also track maternal side effects up to 48 hours after infusion and neonatal health up to 4 weeks after birth.

This research evaluates augmentation techniques for the maxillary sinus floor in patients needing dental implants in areas with reduced bone height. It compares a new hydrogel-enhanced xenograft bone substitute with a graftless method that relies on the body forming bone after elevating the sinus membrane. The study aims to assess differences in tissue reaction, bone height, and bone quality between these two approaches. Participants undergo lateral maxillary sinus floor elevation either with the hydrogel-enhanced xenograft or with a graftless method involving stabilization of the elevated membrane using screws. This is done as a staged procedure, with implant placement planned after bone augmentation. The study includes two randomized groups one receiving the xenograft material and the other using membrane stabilization without graft material. During the study, participants will be monitored for postoperative swelling, pain, and tissue response. Radiographic imaging via CBCT will assess bone height and density before implant placement at 8 months. Bone samples will be collected for histological examination. Participant involvement includes follow-up visits to track healing and collect patient-reported symptoms, with the total study duration extending through the augmentation and implant preparation phases.

This clinical trial studies patients who need extraction and immediate dental implant placement in the upper premolar area. It evaluates the effect of using an autologous demineralized dentin graft ADDG, either alone or combined with melatonin gel, on helping the implant bond with the bone, a process called osseointegration. The study aims to see if melatonin, an antioxidant that may promote bone healing, improves implant success and healing outcomes over 9 months. Participants will be randomly assigned to one of two groups. One group receives immediate implant placement with the gap around the implant filled using ADDG alone, made from the patients extracted tooth processed into graft material. The other group receives the same graft mixed with melatonin gel applied locally around the implant. Both groups will have their implants placed in the maxillary premolar region using standard surgical techniques. Throughout the 9-month follow-up, patients will undergo clinical exams and imaging to measure implant stability, gum health, bone loss, bone thickness, and bone density at various times. Assessments include probing depth, bleeding index, and cone beam CT scans. The study tracks changes from baseline to 6 and 9 months after implant placement to compare healing and bone integration between the two treatment methods.

Researchers are studying the combined effect of sensory-motor integration on individuals with postmenopausal polyneuropathy, a condition affecting nerve function and balance. The study aims to improve balance and reduce pain in women who have peripheral neuropathy after menopause, especially those with Type II Diabetes Mellitus and numbness in their limbs lasting more than four months. Participants will be randomly assigned to one of two groups. One group will receive sensory motor integration therapy, which includes tactile, thermal, and proprioceptive stimulation along with strengthening exercises and pelvic rocking training for six weeks. The other group will receive conventional exercises, involving free and gymnasium exercises for the upper and lower limbs plus 20 minutes of walking. During the six-week study, participants will be assessed for pain intensity and balance. Researchers will monitor changes in these measures to understand the effects of the different exercise programs. The study is sponsored by New Ismailia National University and includes women aged 45 to 55 years. Participants progress and safety will be monitored throughout the trial period.

This research aims to evaluate and compare the pulp response in young permanent first molars after an apexogenesis procedure using melatonin versus mineral trioxide aggregate MTA. The study focuses on children aged 6 to 8 years with dental caries affecting these teeth, exploring whether melatonin, known for its role in bone growth regulation, has effects similar to MTA in vital pulp therapy. Participants will be divided into three groups of 15 teeth each one treated with MTA, another with melatonin powder mixed with saline, and the third with a mixture of MTA and melatonin powders. After the apexogenesis procedure, the selected material is placed as a sub base in the pulp chamber, followed by a permanent restoration using glass ionomer cement. Immediate postoperative digital x-rays will be taken, with follow-up visits scheduled at 1, 3, 6, 9, and 12 months to monitor progress. During the study, clinical assessments will include modified visual analogue scales, Millars index, and checks for presence or absence of symptoms, alongside radiographic evaluations using Image J software at all follow-up points. These evaluations will help measure the healing and response of the pulp to the treatments. The total participation duration is 12 months, with monitoring for any pulp healing, inflammation, and radiographic changes.

Researchers are comparing two protocols for intravenous insulin infusion to improve blood sugar control in diabetic critically ill adults admitted to intensive care units at Suez Canal University SCU hospitals. The study aims to find out whether the SCU protocol is more effective than the National Health System NHS protocol used in the UK for managing blood glucose levels in these patients. This comparison will help determine the best way to control blood sugar in critically ill diabetic adults. Participants will be randomly assigned to one of two groups one group will follow the SCU insulin infusion protocol, while the other will follow the NHS protocol. Both groups will receive regular insulin through an intravenous infusion, with doses adjusted according to their assigned protocol and blood sugar levels. Nurses will prepare and monitor the insulin infusion carefully, stopping it if blood sugar falls below 80 mgdl. Potassium levels will be regularly checked and managed based on specific guidelines during the study. During the study, patients will have routine blood tests, including daily checks and more frequent potassium monitoring if needed. Researchers will collect information on their medical history, nutrition, mechanical ventilation duration, and any complications like diabetic ketoacidosis or hypoglycemia. Outcomes such as time to reach target blood glucose, ventilator-free days, ICU and hospital stay lengths, and mortality rates will be evaluated. The study will last up to 28 days, with ongoing assessments to monitor patients progress and safety.

Researchers are evaluating the efficiency of direct 3D printed aligners in moving the crowns of upper and lower front teeth in adults with spacing issues during orthodontic space closure. This study focuses on comparing the actual tooth movements achieved with these aligners to the predicted movements planned before treatment. The trial will include adult patients aged 18 to 45 years with specific dental conditions, such as Angle Class I or mild Class II malocclusions and spacing between anterior teeth. Participants will receive direct 3D printed aligners designed after intraoral scans and 3D digital simulations of their teeth. Patients will be instructed to wear the aligners and to activate their shape memory by placing them in warm water before use. Aligners will be changed every 10 days throughout the treatment period, which lasts between 9 to 12 months. At the end of treatment, a new 3D scan will be taken to compare the actual tooth movements with the planned movements using digital superimposition techniques. During the study, patients will undergo intraoral scans before and after treatment, and 3D digital models will be created to measure crown movement in millimeters. These measurements will be analyzed statistically to determine the aligners effectiveness in achieving planned tooth movements. The study includes careful monitoring of dental health and malocclusion status, with no blinding or control group. The total duration of treatment and observation will be 9 to 12 months.

Researchers are evaluating the combined effect of Extracorporeal Shock Wave Therapy ESWT and core stability exercises on chronic non-specific back pain among female university students in Jordan. This condition often involves muscle weakness, poor posture, and soft tissue problems. The study aims to assess how these treatments together can reduce pain and improve physical function and balance. Participants will be randomly assigned to one of two groups. One group will receive ESWT along with core stabilization exercises, while the control group will perform core stabilization exercises combined with therapeutic ultrasound. The study starts in December 2025 and measures outcomes over 12 weeks. During the study, participants will undergo treatment sessions and perform exercises as scheduled. Researchers will assess back pain, physical function, and balance at 12 weeks. The study involves female students aged 16 to 18 who experience chronic non-specific back pain. Monitoring will focus on changes in pain and functional improvement throughout the treatment period.

Researchers are evaluating how combining virtual reality with plyometric workouts affects abdominal obesity in adolescent females. This randomized clinical trial focuses on females aged 13 to 18 years who have abdominal obesity and a medical history of polycystic ovarian syndrome. The study aims to measure changes in waist circumference, waist-hip ratio, body mass index, and lung function over a 12-week period. A total of 100 adolescent females will be randomly assigned to two groups of 50 each. Study Group A will perform immersive virtual reality exercises combined with plyometric and abdominal workouts. Study Group B will engage in treadmill aerobic training combined with the same plyometric and abdominal exercises. Both groups will follow their respective programs consistently for three months. Participants will have key physical measurements and lung function tests taken before starting and after completing the treatment program. These include waist circumference, waist-hip ratio, body mass index, and pulmonary function assessed by electronic spirometry. The trial will monitor these outcomes to assess any improvements or changes related to the combined exercise approaches over the 12 weeks of study.