Ivry Sur Seine

This research aims to find out how common cardiac amyloidosis is among older adults aged 80 years and above who have been hospitalized for heart failure and show thickening of the hearts left ventricle. The study is observational and conducted across multiple geriatric and cardiology centers. It focuses on patients who have experienced heart failure with specific heart muscle changes seen on echocardiography. Participants will be recruited over 24 months and followed for 12 months. At the start, researchers will collect medical history, demographic information, clinical data, frailty status, biological and genetic tests, and echocardiogram results. Bone scans using specific tracers will be performed during or after hospital stays to check for heart muscle involvement. Follow-up will include phone calls every three months to track hospitalizations, care facility admissions, and survival. During the study, participants will have regular assessments including frailty scales, cognitive tests, and questionnaires related to neuropathic pain and independence in daily activities. Researchers will evaluate bone scan results to detect amyloidosis and measure other health and functional outcomes. The study aims to provide a clearer picture of cardiac amyloidosis prevalence and patient condition over one year.

Researchers are studying Sjgrens syndrome SS, a rare autoimmune disease that damages the glands that produce saliva. This condition can lead to dry mouth, which may increase the risk of dental problems like tooth wear, inflammation, and gum recession. The study aims to understand how common these dental and gum issues are in people with SS and how they relate to saliva changes and oral quality of life. This observational study collects saliva samples and dental assessments from patients with Sjgrens syndrome during their regular visits to the oral medicine department. The saliva samples will be stored for future research. The study will follow patients annually for five years to measure dental wear, gum recession, gum inflammation, and tooth decay, along with saliva characteristics like dryness, flow rates, pH, and buffering capacity. Participants will have yearly evaluations for five years as part of their routine care, including dental exams and saliva tests. Researchers will analyze the prevalence of dental and gum problems and explore connections between oral health, saliva quality, and patients quality of life. The study will last a total of ten years, including five years of patient follow-up, to help better understand oral health challenges in Sjgrens syndrome.

Sarcopenia is a progressive muscle disorder common in older adults, characterized by loss of muscle mass, strength, and physical performance. This condition increases risks of falls, frailty, and mortality. Researchers are exploring the use of high-definition surface electromyography HD-sEMG to develop a new, non-invasive diagnostic method for sarcopenia. The study targets people aged 75 and older who are hospitalized and suspected of having sarcopenia based on a screening questionnaire score. Participants will undergo HD-sEMG to record muscle activation signals from the rectus femoris muscle during knee movements or chair rises. Additional assessments include body composition via bioimpedancemetry and possibly DEXA scans, muscle strength tests using handgrip measurements, and physical performance evaluations. The study is descriptive and cross-sectional, conducted across multiple centers, with a planned inclusion period of 18 months and a 3-month follow-up after inclusion. Throughout the study, participants will provide data through muscle ultrasound and physical activity questionnaires. Researchers will analyze HD-sEMG signals to differentiate between sarcopenic and non-sarcopenic individuals and to monitor functional recovery and muscle parameters over time. Outcomes include correlations with muscle mass, strength, physical performance, and quality of life. The total study duration is 21 months, with assessments conducted from day 1 through day 90 after inclusion.

Sarcopenia is a progressive muscle disorder marked by the loss of muscle mass and function, leading to increased risks like falls, frailty, and death. This study aims to explore a new, non-invasive diagnostic method using high-definition surface electromyography HD-sEMG technology to better identify sarcopenia in older adults. The research is a monocentric, descriptive, cross-sectional pilot project including people aged 75 and older who are hospitalized and suspected of sarcopenia based on a screening questionnaire score. Participants will undergo the HD-sEMG procedure, which records muscle activation signals from the rectus femoris muscle during knee extension, either lying down or sitting, depending on their ability. Additional assessments include muscle ultrasounds using a handheld device, physical activity questionnaires, and body composition analysis via DEXA scans. Muscle strength will be measured through handgrip tests, and physical performance will be evaluated using established scoring methods. During the study, participants will have various assessments including muscle mass, fat thickness, and electromyographic signals collected within the first week after inclusion, with follow-up HD-sEMG muscle data collected one month later. Researchers will also track falls, mortality rates, and other health indicators through medical records. The total duration for each participant is 37 months, including 36 months for inclusion and a one-month follow-up as part of routine care.

This research focuses on patients with Wilson disease, a condition affecting copper metabolism, and aims to compare oral health between those with hepatic and neurological forms of the disease and a control group without Wilson disease. It highlights that patients with Wilson disease often have poorer dental and periodontal health and a lower oral quality of life. Neurological patients may have more difficulty with jaw function, and treatments for Wilson disease can cause oral mucosa lesions. The study is observational and involves patients and controls undergoing dental health assessments. Participants include patients diagnosed with Wilson disease in either hepatic or neurological forms, as well as control individuals attending routine dental consultations outside emergency or treatment follow-up contexts. The study evaluates dental health using the CAOD index, which measures the severity of caries by counting decayed, absent, and filled permanent teeth. Data collection involves clinical dental exams, panoramic dental imaging, saliva sample collection, and an oral quality of life questionnaire called OHIP-14. During the study, participants undergo a detailed dental examination and provide saliva samples to assess copper levels, which may indicate treatment effectiveness. Controls complete the same oral exams and questionnaires to allow comparison. The primary outcome is the CAOD index score measured at the inclusion visit. The study monitors oral health differences among groups to better understand the impact of Wilson disease on dental conditions. Participation involves one visit with clinical, imaging, and questionnaire assessments.

Cystic Fibrosis CF is a rare inherited disease caused by a mutation in the CFTR gene, affecting various organs including the lungs and oral health. This research aims to better understand the oral health profile of adults with CF, as previous studies mainly focused on children. With increasing life expectancy due to treatments like Kaftrio, more adults now live with CF, raising new concerns about oral health and its impact on respiratory complications. The study uses an online questionnaire developed with the Vaincre la Mucoviscidose patient association. It collects data on dental care, periodontal health, tooth wear, caries risk, mouth dryness, and oral quality of life using recognized international tools. The survey also checks if patients follow recommended oral hygiene practices and dental check-ups. The questionnaire will be shared widely among adult CF patients in France through newsletters, social networks, and care centers. Participants will complete the questionnaire providing information on their oral health status and habits. Researchers will evaluate periodontal risk scores, oral hygiene adherence, caries and tooth wear risks, oral dryness, and quality of life. The study focuses on real-life data from adults with CF, aiming to identify their specific oral care needs. Participation involves answering the survey, with results helping improve dental care recommendations for this population.

Researchers are studying the immune and inflammatory responses involved in bone destruction during periodontitis and peri-implantitis. The goal is to identify specific molecular markers that reflect disease activity, improve understanding of disease mechanisms, and find potential therapeutic targets. This observational study collects biological samples from patients with stage 3 or 4 periodontitis or peri-implantitis, as well as from patients with healthy gums requiring surgical care, to compare molecular profiles and immune responses. Participants are grouped into three categories those with stage 3 or 4 periodontitis, those with peri-implantitis affecting at least one implant, and controls with healthy gums needing surgery for other dental reasons. Biological samples such as plaque, saliva, gingival fluid, and gingival tissue during surgery are collected. Cases receive periodontal or peri-implantitis treatment including non-surgical care, possible surgery if needed, and follow-up evaluations. Controls undergo surgical procedures like dental avulsion or pre-prosthetic surgery with sample collection and healing monitoring. Throughout the study, clinical data and biological samples will be collected at inclusion and multiple follow-up points to analyze inflammatory mediators, cytokines, proteases, and bacteria. Researchers will use techniques like Luminex and quantitative PCR to characterize immune markers and microbial profiles. The primary outcome is the analysis of cytokines in gingival fluid. Secondary outcomes include cytokine expression in cells, protease characterization, and microbiological biofilm analysis. The study follows patients as part of their routine care without additional follow-up, lasting up to 60 months for recruitment and sample collection.

Researchers are studying children with Down syndrome or trisomy 21 DST21 to better understand how their immune cells, specifically neutrophils, may contribute to early gum disease called periodontitis. This condition is more common and severe in young people with DST21 under 35 years old, but little is known about the role of immune deficiency in these cases. The study focuses on identifying different types of neutrophils in the mouth and blood of children with DST21 who have signs of gum inflammation. This is a non-randomized, open-label study involving two groups children with DST21 and control children without DST21. The DST21 group is further divided based on gum health. Control children include those with psychomotor retardation without immune or oral issues as well as healthy children, also divided by gum health. Researchers will collect saliva and blood samples during routine care at a hospitals oral medicine department over 12 months to analyze neutrophil subtypes using flow cytometry. Participants will provide saliva and blood samples without additional follow-up visits beyond their usual care. The study will examine neutrophil markers to distinguish different subtypes and assess their presence in saliva and blood during health and inflammation. This will help understand the immune cell involvement in early gum disease in children with DST21. The study runs from April 2025 to April 2027, with safety and data collection integrated into routine clinical care.

Periodontitis is a widespread chronic inflammatory disease in adults that causes permanent damage to the tissues supporting the teeth. It is linked to oral bacteria like Porphyromonas gingivalis and involves an abnormal immune response. This study aims to understand the role of different neutrophil subtypes, a type of immune cell, in the progression from gingivitis to periodontitis and their involvement in tissue destruction. Researchers seek to identify specific neutrophil interactions with the oral environment and bacteria to better detect patients at risk for periodontitis. The study is an observational, cross-sectional case-control design conducted at a single center. It includes three groups of adult patients requiring dental surgery those with periodontitis, gingivitis, or healthy gums. Participants will provide biological samples such as tissue, saliva, blood, and gingival fluid during routine surgical care. Sampling includes tooth extraction with gingival tissue collection and follow-up visits to monitor healing. The study collects data over a 36-month inclusion period without additional follow-up specific to the research. Participants will have various samples collected and analyzed to identify neutrophil subtypes and their interactions with tissue proteins and oral bacteria through advanced imaging techniques. Researchers will assess neutrophil function and their role in bone resorption related to periodontitis. The primary outcome measures focus on neutrophil subtype characterization, while secondary outcomes evaluate neutrophil interactions and activity. The total participation is aligned with usual patient care timelines and includes healing assessments after tissue sampling.