Ivry Sur Seine

This research aims to find out how common cardiac amyloidosis is in older adults aged 80 years and above who have been hospitalized for heart failure and have thickening of the heart muscle (left ventricular hypertrophy). Patients will be recruited from 31 geriatric or cardiology centers over 24 months. Each participant will have a baseline visit where medical history, clinical data, frailty status, genetic testing, and heart ultrasound data will be collected. Bone scans using 99mTc-DPD or 99mTc-HMDP will be done during or after hospitalization to check for amyloidosis in the heart muscle. After the initial visit, participants will receive follow-up phone calls every 3 months for 12 months to track hospitalizations, nursing home admissions, and death. The main measure is the number of patients diagnosed with cardiac amyloidosis based on bone scintigraphy at the start of the study.

Sjf6gren's syndrome is a rare chronic autoimmune disease that causes damage to the salivary glands and other exocrine glands, leading to reduced saliva production. This condition increases the risk of dental problems like caries and dental wear, although dental wear has not been widely studied in these patients. The study aims to assess how common dental wear and gum recession are in people with Sjf6gren's syndrome, using specific scores and measurements to analyze tooth erosion, attrition, and gum recession. The study involves collecting saliva samples from patients with Sjf6gren's syndrome who are receiving routine care at the oral medicine department of AP-HP Charles Foix hospital. These samples will be stored in a biological collection for future research. The study is observational and non-interventional, tracking dental and gum health without changing patients' treatments. The research will take place over an inclusion period of 5 years, with 5 years of follow-up, totaling 10 years. Participants will be examined yearly for 5 years to measure dental wear and gum recession. Researchers will assess saliva dryness, saliva flow rates, pH, and buffer capacity, along with oral health indices like dental decay and gum inflammation. The study will investigate how these factors relate to dental and periodontal health. The long-term follow-up allows for ongoing monitoring of these oral health outcomes in patients with Sjf6gren's syndrome to better understand the disease's impact.

Sarcopenia is a condition characterized by the progressive loss of muscle mass and strength in older adults, leading to higher risks of falls, frailty, functional decline, and mortality. This research aims to develop a new diagnostic method for sarcopenia using high-definition surface electromyography (HD-sEMG) technology, which captures muscle activation signals. The study is multicentric, descriptive, cross-sectional, and involves parallel groups, focusing on people aged 75 years and older who are suspected of having sarcopenia based on the SARC-F screening questionnaire score. Participants will undergo muscle signal recording using HD-sEMG on the rectus femoris muscle during knee extension exercises either lying down or standing up from a chair, depending on their functional ability. Additional assessments include quadriceps muscle ultrasound performed at the bedside using a wireless handheld device and evaluation of physical activity using a questionnaire adapted for seniors. Body composition will be measured by bioimpedancemetry and, when possible, by dual X-ray absorptiometry (DEXA). Muscle strength will be tested through handgrip strength, and physical performance will also be assessed. During the study, participants' medical records will be reviewed for relevant clinical data. The primary outcome is the diagnostic score derived from electromyographic signals collected over seven days to differentiate sarcopenic from non-sarcopenic elderly individuals. The inclusion period will last 18 months, with an additional 3-month follow-up, totaling 21 months. This study seeks to provide a non-invasive and portable tool for sarcopenia diagnosis and monitoring, combining muscle mass and functional evaluation in older adults.

Sarcopenia is a progressive muscle disorder characterized by loss of muscle mass and function, leading to higher risks of falls, frailty, and mortality. This research explores the use of high-definition surface electromyography (HD-sEMG) as a new, non-invasive way to diagnose sarcopenia. The study focuses on people aged 75 and older who are suspected of having sarcopenia based on a specific screening questionnaire score. Participants will undergo recordings of muscle activity using HD-sEMG on the rectus femoris muscle during knee extension in different positions depending on their abilities. Additional assessments include quadriceps muscle ultrasound performed at the bedside and a physical activity questionnaire designed for seniors. This is a descriptive, cross-sectional study conducted at one center over 36 months, with an additional month of routine care follow-up. During the study, participants will have their body composition measured by dual X-ray absorptiometry (DEXA), muscle strength tested by handgrip, and physical performance evaluated. Medical records will be reviewed for further data. The main outcome is the electromyographic signals collected by HD-sEMG over a week. Participants’ overall health and muscle function will be monitored to assess the potential of HD-sEMG as a diagnostic tool for sarcopenia.

Researchers are investigating oral health differences between patients with Wilson disease, specifically comparing those with hepatic and neurological forms, and a control group without the disease. Wilson disease patients often have poorer dental and periodontal health and a lower oral quality of life than people without the disease. Those with the neurological form may experience more difficulties with chewing function. The study also examines how systemic treatments for Wilson disease might cause lesions in the mouth, and whether copper levels in saliva can indicate the effectiveness of treatment in reducing copper. The study involves collecting saliva samples and conducting thorough dental exams on all participants. Patients complete an oral quality of life questionnaire, and control participants undergo a detailed standardized oral examination along with the same questionnaire. Dental health is assessed using the CAOD index, which counts the number of permanent teeth that are decayed, missing due to decay, or filled, with a maximum score of 28. Panoramic dental imaging supports these evaluations. Participants will have clinical dental examinations and saliva collection, along with completing questionnaires to assess their oral quality of life. Researchers will measure the severity of tooth decay and analyze saliva copper levels to monitor treatment effects in Wilson disease patients. The study compares these findings between the hepatic form, neurological form, and control participants to better understand oral health impacts. Safety and eligibility criteria are applied to protect participants. Total study involvement details are not specified.

Cystic Fibrosis (CF) is a rare inherited disease affecting about 1 in 4700 births in France, caused by a mutation in the CFTR gene that impacts chloride ion transport in epithelial cells. While primarily affecting the lungs, CF also has oral health effects. Previous studies, mostly in children, have shown issues such as reduced saliva production, dental erosion, enamel defects, and fewer cavities, with little increase in gum disease. The oral quality of life for CF patients has been little studied, especially in adults, despite their growing numbers due to improved treatments like Kaftrio®. This research uses an online questionnaire to survey the oral health of adult CF patients across France, developed in collaboration with the patient association Vaincre la Mucoviscidose. The survey collects information on social factors, medical history, dental care habits, risks for gum disease, tooth wear and decay, mouth dryness, and oral quality of life using recognized tools. It also evaluates adherence to French oral health recommendations, such as regular dental check-ups and effective daily oral hygiene practices. Participants will complete the questionnaire remotely, which is distributed through the patient association’s newsletter, social media, and care center posters. Researchers will analyze responses to better understand the oral health profile and care needs of adult CF patients. The main outcome measured is the Periodontal Risk Screening Score after three months. This study gathers real-life data to inform improved dental care and oral health support for people living with CF.

Researchers are studying periodontitis and peri-implantitis, two conditions that cause inflammation and tissue destruction around teeth and implants. The goal is to better understand the molecular markers involved in these diseases to improve prevention, screening, and treatment options. This study aims to identify specific molecules and immune responses linked to tissue damage and to explore how these conditions might affect overall health. The study collects various biological samples including plaque, saliva, gingival fluid, and gingival tissue from patients with stage 3 or 4 periodontitis or peri-implantitis, as well as from patients with healthy gums who need dental surgery. Patients with periodontitis or peri-implantitis receive standard treatments such as oral hygiene education, non-surgical therapy, possible surgery with tissue sampling, and follow-up care. Control patients undergo surgical procedures like dental extractions or corrective gum surgery with tissue sampling and healing checks. Participants provide samples before, during, and after their dental treatments. Researchers analyze these samples using advanced techniques to measure inflammatory molecules, enzymes, and bacteria involved in gum disease. The main outcome is the comparison of cytokine levels in gingival fluid between patients with and without periodontitis. The study lasts up to 60 months with no additional follow-up beyond usual care, and tissue samples are collected during necessary surgeries.

Researchers are examining the link between Down syndrome (DS)/trisomy 21 (T21) and early development of periodontitis in children aged 3 to 12 years. Since 2018, DS/T21 has been recognized as a systemic condition influencing periodontal disease, with many affected youths showing early signs of gum and bone loss. This research aims to understand how specific types of immune cells called neutrophils may contribute to the rapid progression of gum disease in these children. The study is a cross-sectional, open-label, non-randomized case control design conducted at a single center. Participants include children with DS/T21 and controls classified by their periodontal and systemic health. The main procedure involves collecting saliva and blood samples to analyze neutrophil subtypes using flow cytometry, focusing on 24 markers related to neutrophil function. Participants are divided into groups based on their gingival health status and systemic conditions, and samples are collected during routine oral care visits over a 12-month inclusion period. Participants will provide saliva and blood samples during their oral medicine visits, with no additional follow-up required. Researchers will evaluate the types of neutrophils present in both saliva and blood and their association with periodontal health, inflammation, and disease. The primary outcome measures the presence and characteristics of neutrophil subtypes, contributing to understanding immune involvement in early periodontitis among children with DS/T21.

Periodontitis is a widespread chronic inflammatory disease that causes irreversible damage to the tissues supporting teeth and is linked to systemic inflammatory conditions. It often begins with gingivitis, a reversible inflammation of the gums without bone loss. Researchers aim to better understand how different types of neutrophils, key immune cells involved in inflammation, contribute to the progression from gingivitis to periodontitis. This study explores the roles of various neutrophil subtypes in periodontal disease to help identify patients at risk early on. This is a cross-sectional, open-label study conducted at a single center where patients receiving oral surgery care will be grouped into three categories: healthy controls, gingivitis cases, and periodontitis cases. Biological samples including periodontal bacteria, gingival fluid, saliva, and blood will be collected. Gingival tissue will be sampled during surgery, with follow-up visits at 7 and 15 days post-surgery for healing control. The study will observe interactions between neutrophils, the tissue environment, and oral bacteria, and evaluate the function of oral neutrophils compared to those in blood. Participants will undergo biological sampling as part of their routine oral care, with no additional follow-up required by the study. Assessments include advanced imaging and immunohistofluorescence to identify neutrophil subtypes and their interactions with tissue proteins and bacteria. The study will also analyze neutrophils present in saliva and their correlation with tissue samples across healthy and diseased states. The primary outcome is to characterize neutrophil subtypes associated with periodontal tissue destruction over 36 months.