Actively Recruiting

Age: 18Years - 80Years
All Genders
NCT06760273

Long-term Impact of Inhaled Tobramycin for Pseudomonas Aeruginosa Eradication in Bronchiectasis (ERASE II)

Led by Shanghai Pulmonary Hospital, Shanghai, China · Updated on 2025-04-01

364

Participants Needed

58

Research Sites

167 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The ERASE II study is a prospective follow-up study designed to assess the long-term impact of successful eradication of Pseudomonas aeruginosa (PA) in patients with bronchiectasis. Building on the findings of the initial ERASE study, which evaluated the efficacy and safety of Tobramycin Inhalation Solution, ERASE II aims to determine whether successful PA eradication influences patient prognosis over an extended period. The study will involve a total observation period of 36 months, consisting of the initial 9 months of the ERASE study followed by an additional 27 months of comprehensive follow-up. Key outcomes to be assessed include patients' quality of life, lung function, frequency of pulmonary exacerbations, frequency of hospitalization, and overall treatment costs. Additionally, the study will examine the timing and incidence of any potential reinfections with Pseudomonas aeruginosa.

CONDITIONS

Official Title

Long-term Impact of Inhaled Tobramycin for Pseudomonas Aeruginosa Eradication in Bronchiectasis (ERASE II)

Who Can Participate

Age: 18Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • All patients who participate in the ERASE study
  • Signed the informed consent form
Not Eligible

You will not qualify if you...

  • Patients lost to follow-up in the ERASE study
  • Considered ineligible by the researcher for other reasons

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 58 locations

1

Anhui Chest Hospital

Hefei, Anhui, China

Actively Recruiting

2

The First Affiliated Hospital of Anhui Medical University

Hefei, Anhui, China

Actively Recruiting

3

Beijing Chao-Yang Hospital, Capital Medical University

Beijing, Beijing Municipality, China

Actively Recruiting

4

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, China

Actively Recruiting

5

The Second Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, China

Active, Not Recruiting

6

The Third Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, China

Actively Recruiting

7

Fujian Provincial Hospital

Fuzhou, Fujiang, China

Actively Recruiting

8

The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China

Actively Recruiting

9

The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine

Guangzhou, Guangdong, China

Actively Recruiting

10

Shenzhen Institute of Respiratory Diseases

Shenzhen, Guangdong, China

Actively Recruiting

11

The Eighth Affiliated Hospital of Sun Yat-Sen University

Shenzhen, Guangdong, China

Actively Recruiting

12

Affiliated Hospital, Guangdong Medical College

Zhanjiang, Guangdong, China

Active, Not Recruiting

13

The First Affiliated Hospital of Guangxi Medical University

Nanning, Guangxi, China

Active, Not Recruiting

14

Guizhou Provincial People's Hospital

Guiyang, Guizhou, China

Actively Recruiting

15

Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University

Haikou, Hainan, China

Active, Not Recruiting

16

Henan Provincial People's Hospital

Zhengzhou, Henan, China

Actively Recruiting

17

Zhengzhou People's Hospital

Zhengzhou, Henan, China

Actively Recruiting

18

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China

Actively Recruiting

19

Union Hospital,Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China

Actively Recruiting

20

The Second Xiangya Hospital of Central South University

Changsha, Hunan, China

Actively Recruiting

21

Xiangya Hospital, Central South University

Changsha, Hunan, China

Actively Recruiting

22

The Second Affiliated Hospital of Nanjing Medical University

Nanjing, Jiangsu, China

Actively Recruiting

23

Affiliated Hospital, Nantong University

Nantong, Jiangsu, China

Actively Recruiting

24

The Sixth People's Hospital of Nantong City

Nantong, Jiangsu, China

Actively Recruiting

25

Suzhou Science and Technology Town Hospital

Suzhou, Jiangsu, China

Actively Recruiting

26

The First Affiliated Hospital of Soochow University

Suzhou, Jiangsu, China

Actively Recruiting

27

Subei People's Hospital

Yangzhou, Jiangsu, China

Actively Recruiting

28

The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, China

Actively Recruiting

29

Shangrao People's Hospital

Shangrao, Jiangxi, China

Actively Recruiting

30

The First Affiliated Hospital of Jilin University

Changchun, Jilin, China

Actively Recruiting

31

The Second Affiliated Hospital of Dalian Medical University

Dalian, Liaoning, China

Actively Recruiting

32

Shengjing Hospital of China Medical University

Shenyang, Liaoning, China

Actively Recruiting

33

The First Affiliated Hospital of China Medical University

Shenyang, Liaoning, China

Actively Recruiting

34

Qilu Hospital of Shandong University

Jinan, Shandong, China

Actively Recruiting

35

Qingdao Municipal Hospital

Qingdao, Shandong, China

Actively Recruiting

36

The First Affiliated Hospital of Shandong First Medical University

Jinan, Shangdong, China

Active, Not Recruiting

37

Ruijin Hospital

Shanghai, Shanghai Municipality, China, 200025

Actively Recruiting

38

The Shanghai Fifth People's Hospital

Shanghai, Shanghai Municipality, China, 200245

Actively Recruiting

39

Shanghai pulmonary hospital

Shanghai, Shanghai Municipality, China, 200433

Actively Recruiting

40

Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine

Shanghai, Shanghai Municipality, China

Actively Recruiting

41

Shanghai Eighth People's Hospital

Shanghai, Shanghai Municipality, China

Actively Recruiting

42

Shanghai General Hospital

Shanghai, Shanghai Municipality, China

Actively Recruiting

43

Shanghai Putuo District People's Hospital

Shanghai, Shanghai Municipality, China

Actively Recruiting

44

Shanghai Sixth People's Hospital

Shanghai, Shanghai Municipality, China

Actively Recruiting

45

Zhongshan Hospital, Fudan University

Shanghai, Shanghai Municipality, China

Actively Recruiting

46

Shanxi Bethune Hospital

Taiyuan, Shanxi, China

Active, Not Recruiting

47

West China Hospital of Sichuan University

Chengdu, Sichuan, China

Actively Recruiting

48

The First People's Hospital of Anning City Affiliated to Kunming University of Science and Technology

Anning, Yunnan, China

Actively Recruiting

49

The First Affiliated Hospital of Kunming Medical University

Kunming, Yunnan, China

Active, Not Recruiting

50

The Affiliated Hospital of Hangzhou Normal University

Hangzhou, Zhejiang, China

Actively Recruiting

51

The Second Affiliated Hospital of Zhengjiang University

Hangzhou, Zhejiang, China

Actively Recruiting

52

Huzhou Central Hospital

Huzhou, Zhejiang, China

Actively Recruiting

53

The First Hospital of Jiaxing City

Jiaxing, Zhejiang, China

Actively Recruiting

54

The Second Hospital of Jiaxing City

Jiaxing, Zhejiang, China

Active, Not Recruiting

55

Fenghua District People's Hospital of Ningbo City

Ningbo, Zhejiang, China

Actively Recruiting

56

Ningbo Medical Center Lihuili Hospital

Ningbo, Zhejiang, China

Actively Recruiting

57

The First Affiliated Hospital of Ningbo University

Ningbo, Zhejiang, China

Actively Recruiting

58

The First Affiliated Hospital of Wenzhou Medical University

Wenzhou, Zhejiang, China

Actively Recruiting

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Research Team

J

Jin-Fu Xu

CONTACT

J

Jin-Fu Xu, PhD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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