Study of Low-grade Gliomas in Argentina Tracking Incidence and Patient Survival with Treatment Analysis

What this Trial Is About

Researchers are investigating low-grade gliomas LGG, which are slow-growing brain tumors classified as WHO grades I-II. The study aims to better understand the incidence, survival rates, and treatment approaches for LGG in Argentina, a middle-income country where such data are limited. This retrospective, multicenter observational study includes two groups one to estimate LGG incidence and another to assess survival outcomes and treatment patterns. The study involves two cohorts Cohort 1 includes adult members of the Hospital Italiano de Buenos Aires Health Plan from 2011 to 2023 to estimate LGG incidence density. Cohort 2 consists of adults with histologically confirmed LGG treated at major centers during the same period, with follow-up up to 5 years to describe overall survival and disease-free survival. Data on demographics, tumor characteristics, molecular mutations, treatments, and outcomes will be collected and analyzed. Participants medical records will be reviewed to gather clinical, pathological, radiological, and treatment information, which will be entered into a secure, centralized database. Researchers will evaluate incidence rates, survival, and prognostic factors using statistical methods such as Kaplan-Meier curves and Cox regression. The study helps fill gaps in LGG knowledge in Argentina and supports future research, with data confidentiality ensured through anonymization and secure storage.

Low-grade Gliomas in Argentina: Incidence, Survival, and Therapeutic Strategies