Study of Bone Damage and Oxidative Stress Markers in Saliva and Gum Fluid of Adults with Peri-implantitis and Periodontal Diseases

What this Trial Is About

Researchers are studying how certain markers related to bone breakdown, oxidative stress, and inflammation appear in saliva and fluid around dental implants and gums. They are comparing these markers among people with peri-implantitis, periodontitis, and healthy individuals to understand their potential in detecting early stages and progression of peri-implant diseases. This observational study follows classifications from the 2017 World Workshop on Periodontal and Peri-Implant Diseases. Participants will be grouped into four categories based on clinical and radiographic exams peri-implantitis, periodontitis, peri-implant health, and periodontal health. Samples of saliva and peri-implant sulcular fluid are collected under controlled conditions to measure levels of IL-1, Nitrotyrosine, RANKL, OPG, and NQO1 using laboratory ELISA tests. Clinical parameters such as plaque, gingival inflammation, bleeding, probing depth, and attachment loss are also recorded. During the study, participants undergo clinical examinations and biological sample collections at baseline. Researchers monitor various markers in saliva and peri-implant fluid to assess bone destruction and oxidative stress. The study tracks dental and periodontal health indicators to analyze their relationship with these biomarkers. Participation lasts from initial screening until the final data collection, with no treatment administered.

Markers of Bone Destruction and Oxidative Stress in Peri-implantitis