Study of How Methyl-Nutrient Levels During Pregnancy Affect Babys Brain Development and Growth

What this Trial Is About

Researchers are studying how maternal methyl-nutrient levels during pregnancy affect infant brain development and growth. This observational study focuses on nutrients like choline, folate, betaine, and vitamin B12, measuring their intake and blood levels at different pregnancy stages. It also explores genetic, metabolic, and gut microbiome factors to understand how these may influence child development up to 24 months old. Pregnant women aged 20 to 45 receiving care and planning to deliver at a specific hospital are enrolled. Throughout pregnancy, researchers collect dietary information, blood, and stool samples each trimester. At birth, newborn measurements and samples including cord blood and meconium are taken. Children are then followed and assessed for neurodevelopment at 6, 12, and 24 months using well-recognized developmental scales. Participants will visit the study site regularly for sample collection and developmental testing. Researchers analyze blood markers, DNA methylation, gene expression, and gut bacteria to build a detailed picture of influences on early brain development. The study lasts from early pregnancy through the childs first two years, aiming to guide future nutrition recommendations during pregnancy and early childhood.

Maternal Methyl-Nutrient Status and Infant Neurodevelopment Study