Actively Recruiting

Age: 18Years +
All Genders
Healthy Volunteers
NCT07393841

Molecular Indicators of Systematic Fitness

Led by VO Health, Inc. · Updated on 2026-02-06

250

Participants Needed

1

Research Sites

122 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this study is to characterize associations between cardiorespiratory fitness, as measured by VO₂max/VO₂peak, and blood-based molecular measurements in adults. This is an observational study where research staff measures VO₂max/VO₂peak and collects fasted, resting blood samples on the same day. The main questions it aims to answer are: 1. Can a multi-analyte blood panel accurately predict directly measured VO₂max/VO₂peak? 2. How do these blood-based features vary across age, sex, and self-reported or documented physical activity profiles? 3. Are the predictor analytes able to capture changes in VO₂max/VO₂peak caused by a self-directed intervention (e.g., training for a marathon)? 4. What is the analytic reliability of the predictor biomarkers?

CONDITIONS

Official Title

Molecular Indicators of Systematic Fitness

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Be 18 years old or older
  • Able to understand and provide informed consent
  • Willing to complete VO2max testing, blood draw, and questionnaires
  • Able to safely perform maximal or symptom-limited exercise testing as determined by PAR-Q+ screening and resting heart rate assessment
Not Eligible

You will not qualify if you...

  • Conditions making maximal exercise testing unsafe, as judged by investigator or doctor (e.g., unstable cardiovascular symptoms)
  • Contraindications or unwillingness to undergo blood draw
  • Acute illness such as fever or significant respiratory illness at testing time
  • Failure to comply with study procedures

AI-Screening

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Trial Site Locations

Total: 1 location

1

VO Health, Inc.

New Haven, Connecticut, United States, 06510

Actively Recruiting

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Research Team

B

Brooks P Leitner, MD, PhD

CONTACT

S

Sean P Langan, PhD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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