Actively Recruiting
Montalcino Aortic Consortium: Precision Medicine for Heritable Thoracic Aortic Disease
Led by The University of Texas Health Science Center, Houston · Updated on 2026-02-02
5000
Participants Needed
20
Research Sites
1072 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The Montalcino Aortic Consortium (MAC) will provide the infrastructure to assemble large cohorts of patients with mutations in known heritable thoracic aortic disease (H-TAD) genes, define the phenotype associated with these genes, and determine genetic and environmental modifiers of H-TAD.
CONDITIONS
Official Title
Montalcino Aortic Consortium: Precision Medicine for Heritable Thoracic Aortic Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients and their relatives with a confirmed pathogenic, likely pathogenic variant, or variant of unknown clinical significance in at least one of the H-TAD genes (TGFBR1, TGFBR2, SMAD3, TGFB2, TGFB3, ACTA2, MYH11, MYLK, PRKG1, MAT2A, MFAP5, LOX, COL3A1, FOXE3, and FBN1)
- Patients of all ages, sex, and race for which informed consent can be obtained
You will not qualify if you...
- Patients without a confirmed causative variant for heritable thoracic aortic disease (H-TAD)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 20 locations
1
HOAG memorial hospital presbyterian
Newport Beach, California, United States, 92663
Actively Recruiting
2
Hoag Memorial Hospital Presbyterian
Newport Beach, California, United States, 92663
Actively Recruiting
3
Sutter Health
Sacramento, California, United States, 95816
Actively Recruiting
4
University of Kentucky
Lexington, Kentucky, United States, 40536
Actively Recruiting
5
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
6
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
7
Washington University in St. Louis
St Louis, Missouri, United States, 63110
Actively Recruiting
8
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Actively Recruiting
9
St. Francis Hospital (Catholic Health)
Roslyn, New York, United States, 11576
Actively Recruiting
10
Oregon Health & Science University
Portland, Oregon, United States, 97239
Actively Recruiting
11
Baylor College of Medicine
Houston, Texas, United States, 77030
Actively Recruiting
12
Texas Children's Hospital
Houston, Texas, United States, 77030
Actively Recruiting
13
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030
Actively Recruiting
14
Inova Health System
Falls Church, Virginia, United States, 22042
Actively Recruiting
15
University of Sydney
Sydney, New South Wales, Australia, 2006
Actively Recruiting
16
Ghent University Hospital (UZ Gent)
Ghent, East Flanders, Belgium, 9000
Actively Recruiting
17
Foothills Medical Centre / Alberta Health Services
Calgary, Alberta, Canada, T2N 2T9
Actively Recruiting
18
Toronto General Hospital (UHN)
Toronto, Ontario, Canada, M5G 2C4
Actively Recruiting
19
Hospital Universitari Vall d'Hebron
Barcelona, Catalonia, Spain, 08035
Actively Recruiting
20
Great Ormond Street Hospital
London, England, United Kingdom, WC1N 3JH
Actively Recruiting
Research Team
D
Dianna M Milewicz, MD, PhD
CONTACT
E
Ernesto Calderon Martinez, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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