Studying Brain Activity in Adults with Focal Epilepsy Using Implanted Intracranial Electrodes Pre-Surgical Evaluation with Macro-Microelectrode Recording

What this Trial Is About

Researchers are investigating the mechanisms behind epileptic activities by using intracranial macro and micro electrodes in patients with focal drug-resistant epilepsy who are undergoing pre-surgical evaluation. This study also aims to explore physiological brain functions such as sleep and cognition alongside epilepsy-related brain activity. The research is led by the Institut National de la Sant Et de la Recherche Mdicale in France. The study involves implanting Benkhe-Fried type macro-micro electrodes alongside clinical macroelectrodes in patients during their pre-surgical assessment with intracranial EEG monitoring. These implanted electrodes will record brain activity at multiple levels throughout the clinical investigation, which can last up to four weeks. Participants will be closely monitored during their hospital stay, with continuous recordings capturing single unit and local field potential changes especially at seizure onset and during normal brain function. Researchers will analyze these recordings to understand brain activity related to seizures and physiological states. The total observation and monitoring period can extend up to four weeks during the pre-surgical evaluation phase.

Multi-level Approach of Brain Activity Using Intracranial Electrodes in Epileptic Patients