A Multicenter Registry on the Diagnosis of Patients with Chronic Angina and No Angiographic Coronary Artery Stenosis - Searching a New Acetylcholine Spasm Definition

What this Trial Is About

Researchers are collecting data from patients being tested for microvascular dysfunction and coronary artery spasm in Europe and North America. This observational registry aims to better understand and describe the characteristics of patients with microvascular dysfunction, a condition that significantly affects quality of life but is not well classified. The study focuses on patients with chronic angina without visible coronary artery narrowing. Participants will undergo invasive assessments using coronary pressure wires to evaluate coronary microvascular function and spasm. Measurements include coronary pressure and flow responses to various agents such as acetylcholine, adenosine, and papaverine. Data collected during routine clinical practice will be entered anonymously into the registry. During the study, researchers will analyze invasive measurements to identify different coronary vasomotor function types, assess diagnostic criteria accuracy, and study factors like sex impact and normal coronary flow values. The primary outcome is identification of coronary vasomotor endotypes immediately after invasive testing. Participation involves no additional interventions beyond standard clinical assessments, and data collection is retrospective and observational.

Multicenter Registry on Microvascular Dysfunction - Searching a New Ach Spasm Definition