Actively Recruiting
Multiple Sclerosis Treatment With Autologous Hematopoietic Stem Cell Transplantation in the Netherlands
Led by Amsterdam UMC, location VUmc · Updated on 2024-08-22
24
Participants Needed
2
Research Sites
262 weeks
Total Duration
On this page
Sponsors
A
Amsterdam UMC, location VUmc
Lead Sponsor
S
St. Antonius Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to study the long-term effects of autologous hematopoietic stem cell transplantation (aHSCT) in people with highly active relapsing-remitting multiple sclerosis. The study will evaluate the following items: 1. Disease activity 2. Safety and tolerability of aHSCT 3. Changes in the immune system Participants will be subjected to frequent visits for five years after treatment with aHSCT. During these visits, clinical testing, evaluation by questionnaires, MRI scans and blood sampling will be performed.
CONDITIONS
Official Title
Multiple Sclerosis Treatment With Autologous Hematopoietic Stem Cell Transplantation in the Netherlands
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients approved for autologous hematopoietic stem cell transplantation (aHSCT) treatment for relapsing-remitting multiple sclerosis according to Dutch criteria
You will not qualify if you...
- Known hypersensitivity to medications used for aHSCT
- Clinically relevant health conditions preventing safe use of aHSCT medications
- Severe clinical depression
- Active addiction to drugs or alcohol
- Active infections such as tuberculosis, cytomegalovirus, Epstein-Barr virus, herpes simplex, varicella zoster, viral hepatitis, toxoplasmosis, HIV, or syphilis
- Active cancer or history of cancer except for local basal cell carcinoma or carcinoma in situ of the cervix
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Amsterdam UMC
Amsterdam, Netherlands
Actively Recruiting
2
St. Antonius Hospital
Nieuwegein, Netherlands
Actively Recruiting
Research Team
R
Rick Heijnen, MSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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