Actively Recruiting
Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules
Led by M.D. Anderson Cancer Center · Updated on 2026-06-01
30
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to observe the effects of nanosecond pulsed field ablation (nsPFA) therapy in treating benign thyroid nodules. The study focuses on how the volume of these thyroid nodules changes over time after treatment, as well as the impact on patients' health-related quality of life. It also evaluates ultrasound features of the nodules and monitors any complications that may arise from the procedure. Participants scheduled for ultrasound-guided nsPFA as part of their standard clinical care will be observed. The study collects patient-reported outcomes through questionnaires and monitors changes in nodule size and ultrasound characteristics following the nsPFA treatment. The study includes adults aged 18 to 80 years with biopsy-confirmed benign thyroid nodules larger than 2 cm causing compressive symptoms. During the study, participants will complete quality-of-life questionnaires over an average period of one year. Researchers will assess nodule volume changes, ultrasound features, and any minor or major complications related to the treatment. The study is observational, with no experimental treatment assignment, and participation involves routine clinical care and follow-up assessments until study completion.
CONDITIONS
Brief Title
Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Scheduled to undergo ultrasound guided nsPFA as standard of care
- Age 18 to 80 years
- Capable of providing independent consent
- Presence of biopsy-confirmed benign thyroid nodule, defined as either benign FNA twice, benign US guided FNA once with benign ultrasound appearance (TI-RADS 2), or benign FNA once with radiographic/laboratory evidence of functional nature
- Nodule measuring >2 cm in greatest dimension
- Presence of compressive symptoms reasonably attributable to thyroid nodule (pressure sensation, dysphagia, dysphonia, respiratory distress)
- No abnormal cervical lymph nodes during screening visit
You will not qualify if you...
- Age <18
- Patients considered unsuitable for nsPFA by the treating physician
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Single treatment session
Participants undergo ultrasound-guided nanosecond pulsed field ablation (nsPFA) as part of their routine clinical care for benign thyroid nodules.
1 treatment visit (in-person)
Duration - Up to 1 year
Participants are monitored over approximately 1 year to evaluate thyroid nodule volume changes, quality of life, ultrasound features, and any complications following nsPFA.
Periodic visits for questionnaire and ultrasound assessments
Trial Site Locations
Total: 1 location
1
MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
V
Victoria E Banuchi, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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