Actively Recruiting
The Clinical Outcomes and AI Prediction Model of Ultrasound-guided Thermal Ablation for Benign Thyroid Nodules: A Multicenter Prospective Study
Led by Chinese PLA General Hospital · Updated on 2026-03-19
1500
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the clinical outcomes of ultrasound-guided thermal ablation for treating benign thyroid nodules. This multicenter prospective study also aims to develop and validate an artificial intelligence model to predict the results of this treatment. The study is sponsored by the Chinese PLA General Hospital and focuses on improving care for patients with benign thyroid nodules who may have cosmetic or symptomatic concerns or worries about rapid growth or malignant transformation. The study involves ultrasound-guided thermal ablation procedures, including microwave ablation, radio frequency ablation, and laser ablation, as the experimental intervention. These treatments are performed to reduce the size of thyroid nodules without surgery. Follow-up assessments are planned over an average of six months to monitor treatment effects and any complications. Participants will undergo evaluations of nodule volume reduction, regrowth rates, cosmetic appearance, symptoms, and volume measurements throughout the study. Complications will be tracked during the first week after treatment. The study includes regular monitoring through ultrasound and symptom scoring, with total participation lasting at least six months to assess the long-term effects of the ablation therapy.
CONDITIONS
Brief Title
The Outcomes of Ultrasound-guided Thermal Ablation for Benign Thyroid Nodules
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmation of benign thyroid nodule status by two separate fine-needle aspiration (FNA) or core-needle biopsy (CNB)
- No suspicious malignant features on ultrasound examination
- Presence of cosmetic and/or symptomatic problems or concern about rapid nodule growth or malignant transformation
- Refusal of or ineligibility for surgery
- Willingness and ability to complete follow-up for at least 6 months
You will not qualify if you...
- Follicular neoplasm or malignancy found on biopsy
- Nodules with benign biopsy results but suspicious ultrasound features such as marked hypoechoic areas, ill-defined margins, taller-than-wide shape, or microcalcifications
- Presence of cystic thyroid nodules
- Contra-lateral vocal cord paralysis
- Previous radiation therapy to the head and neck
- Inability to complete follow-up of at least 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 day for the procedure
Participants undergo ultrasound-guided thermal ablation to treat benign thyroid nodules.
1 treatment visit (in-person)
Duration - Approximately 6 months
Participants are monitored for outcomes including nodule volume reduction, regrowth, complications, and cosmetic and symptom scores.
Multiple follow-up visits over 6 months
Trial Site Locations
Total: 1 location
1
Chinese PLA General Hospital
Beijing, China
Actively Recruiting
Research Team
L
Lin Yan, MD.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
1
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