Actively Recruiting
Natural History of Thyroid Function Disorders
Led by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Updated on 2026-06-01
2500
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying patients diagnosed with or suspected to have thyroid function disorders, including hypothyroidism, hyperthyroidism, thyroid hormone resistance, Graves dermopathy, and TSH-secreting pituitary adenomas. The study aims to better understand the natural history, clinical presentation, and genetics of these thyroid conditions. Many tests performed are part of standard medical care for thyroid disorders, with additional blood and tissue samples collected for research and genetic studies. Patients undergo routine history and physical exams, standard endocrine blood and urine tests, TRH tests, thyroid nuclear medicine scans, and measurements of radioiodine or technetium uptake. Imaging studies such as X-rays, CT scans, or MRIs may be done as clinically indicated. The study follows the effects of standard therapies, collects clinical data and biospecimens, and supports future research by creating a repository for thyroid disorders. Participants are evaluated as outpatients or inpatients at the NIH Clinical Center and undergo standard care procedures and tests. Researchers collect clinical data, biospecimens, and genetic samples during these visits. The main outcome measured is the ongoing evaluation of thyroid disorders. The study involves patients from 6 months to 98 years old and includes routine monitoring, laboratory tests, imaging, and clinical assessments to better understand thyroid disease progression and treatment effects.
CONDITIONS
Brief Title
Natural History of Thyroid Function Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with known or suspected thyroid abnormalities, including hypothyroidism, hyperthyroidism, extreme iodine deficiency, and inherited hypothyroidism related to specific gene abnormalities
- Patients with thyroid function test abnormalities due to non-thyroidal illness or abnormalities in serum thyroid hormone binding proteins
- Patients with genetic deficiency of thyroxine-binding globulin or antibodies affecting TSH assay results
- Willingness to comply with all study procedures and availability for the study duration
- Male or female participants aged 6 months and older
- Includes patients with various hyperthyroid conditions such as Graves' disease, subacute and silent thyroiditis, hyperfunctioning thyroid nodules, iodide-induced hyperthyroidism, surreptitious thyroid hormone use, trophoblastic neoplasms, and inappropriate TSH secretion
- Includes patients with various hypothyroid conditions such as primary, secondary, and tertiary hypothyroidism, bio-inactive TSH, and generalized resistance to thyroid hormone
You will not qualify if you...
- There are no exclusion criteria for subjects with known or suspected thyroid abnormalities
Research Team
P
Padmasree Veeraraghavan, R.N.
S
Sriram M Gubbi, M.D.
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