Study of Thyroid Function Disorders Including Hypothyroidism, Hyperthyroidism, and Graves Disease Investigation of Their Natural History, Clinical Features, and Genetics

What this Trial Is About

Researchers are studying patients diagnosed with or suspected to have thyroid function disorders, including hypothyroidism, hyperthyroidism, thyroid hormone resistance, Graves dermopathy, and TSH-secreting pituitary adenomas. The study aims to better understand the natural history, clinical presentation, and genetics of these thyroid conditions. Many tests performed are part of standard medical care for thyroid disorders, with additional blood and tissue samples collected for research and genetic studies. Patients undergo routine history and physical exams, standard endocrine blood and urine tests, TRH tests, thyroid nuclear medicine scans, and measurements of radioiodine or technetium uptake. Imaging studies such as X-rays, CT scans, or MRIs may be done as clinically indicated. The study follows the effects of standard therapies, collects clinical data and biospecimens, and supports future research by creating a repository for thyroid disorders. Participants are evaluated as outpatients or inpatients at the NIH Clinical Center and undergo standard care procedures and tests. Researchers collect clinical data, biospecimens, and genetic samples during these visits. The main outcome measured is the ongoing evaluation of thyroid disorders. The study involves patients from 6 months to 98 years old and includes routine monitoring, laboratory tests, imaging, and clinical assessments to better understand thyroid disease progression and treatment effects.

Natural History of Thyroid Function Disorders