Adverse Events in Neurosurgery: The Novel Therapy-Disability-Neurology Grade.
Alexis Paul Romain Terrapon, Costanza Maria Zattra, Stefanos Voglis...
https://pubmed.ncbi.nlm.nih.gov/33887774Actively Recruiting
Age: 18Years +
All Genders
ID06724029
Neurosurgical Outcome Network for Predicting Outcomes in Neurosurgery
Led by Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Updated on 2026-03-30
4500
Participants Needed
27
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating outcomes and their predictors in various neurosurgical conditions to improve the quality and consistency of research and clinical care. The study focuses on standardizing the assessment of clinical, cognitive, and psychological status before and after neurosurgical interventions across multiple centers. This effort aims to create a common language in routine practice and support better therapeutic decisions through shared data and identified predictive factors. The study collects detailed clinical and demographic information from patients undergoing neurosurgery for a wide range of conditions, including tumors, vascular diseases, trauma, spinal disorders, functional pathologies, peripheral nerve issues, and malformations. Data such as comorbidities, anesthesia details, complications, and psychological assessments are gathered before surgery and at follow-ups, with timing varying by condition. An artificial intelligence analysis will be used to identify important predictors and outcomes. Participants will provide data over a period of up to five years, including sociodemographic details, clinical status, cognitive and psychological assessments, and complication records. The study monitors these factors preoperatively and postoperatively to describe outcomes and explore associations with preoperative indicators. The long-term collection of data supports understanding neurosurgical results and guiding patient care more precisely.
CONDITIONS
Brief Title
Neurosurgical Outcome Network
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Diagnosis of neuro-oncological tumors excluding skull base tumors
- Presence of basicranial tumors from anterior, middle, or posterior cranial fossae or sellar regions
- Vascular pathologies including aneurysms, arteriovenous malformations, cavernomas, Moyamoya disease, dural fistulas, or nontraumatic hematomas
- Traumatic brain injuries such as diffuse damage, subdural or extradural hematomas, subarachnoid hemorrhage, intraparenchymal hematoma, fractures, or hydrocephalus
- Spinal pathologies including degenerative, myelopathic, traumatic, and oncologic conditions
- Functional disorders like Parkinson's disease, spasticity, trigeminal neuralgia, craniofacial pain, neuropathic pain, tremor, dystonias, obsessive-compulsive disorder, drug-resistant epilepsy, depression, or normotensive hydrocephalus
- Peripheral nervous system conditions including nerve compression syndromes, tumors, and trauma
- Malformative conditions such as Chiari malformation type 1, craniostenoses, and malformative hydrocephalus
- Adequate understanding of Italian language
- Diagnosis of glioma, meningioma, vascular pathology, or spinal pathology to qualify for cognitive and psychological assessment
You will not qualify if you...
- History of psychiatric diseases or current use of psychotropic drugs for cognitive and psychological assessments
- Presence of overt cognitive decline not caused by neurosurgical injury
- Age younger than 18 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Up to 1 year
Participants undergo collection of preoperative clinical, cognitive, and psychological data related to their neurosurgical pathology.
Visits as scheduled before surgery depending on pathology
Surgery and Immediate Post-operative Care
Duration - Variable based on intervention and hospitalization
Participants undergo neurosurgical intervention and immediate postoperative clinical care with collection of relevant clinical data.
Hospital visits during intervention and immediate recovery period
Post-operative Follow-up
Duration - Up to 5 years
Participants have follow-up visits to collect postoperative clinical, cognitive, and psychological data to evaluate outcomes and predictors.
Regular follow-up visits scheduled over 5 years depending on pathology
Trial Site Locations
Total: 27 locations
1
1. ASST Papa Giovanni XXIII
Bergamo, BG, Italy, 24127
Active, Not Recruiting
2
Spedali Civili Brescia
Brescia, BS, Italy, 25123
Active, Not Recruiting
3
Fondazione Poliambulanza Istituto Ospedaliero
Brescia, BS, Italy, 25124
Active, Not Recruiting
4
Ospedale Moriggia Pelascini
Gravedona, Como, Italy, 22015
Active, Not Recruiting
5
ASST Lariana, Ospedale S. Anna
Como, CO, Italy, 22100
Active, Not Recruiting
6
ASST Cremona
Cremona, CR, Italy, 26100
Active, Not Recruiting
7
Fondazione IRCCS San Gerardo dei Tintori
Monza, MB, Italy, 20900
Active, Not Recruiting
8
Fondazione IRCCS Policlinico San Matteo
Pavia, PV, Italy, 27100
Active, Not Recruiting
9
ASST della Valtellina ed Alto Lario
Sondrio, SO, Italy, 23100
Active, Not Recruiting
10
Azienda Ospedaliero Universitaria Policlinico "G. Rodolico - San Marco"
Catania, Italy
Actively Recruiting
11
Azienda Ospedaliero Universitaria Careggi
Florence, Italy
Actively Recruiting
12
Ospedale F. Spaziani di Frosinone
Frosinone, Italy, 03100
Actively Recruiting
13
Ospedale Alessandro Manzoni
Lecco, Italy, 23900
Active, Not Recruiting
14
ASST Ovest Milanese
Legnano, Italy, 20025
Active, Not Recruiting
15
Ospedali Riuniti di Livorno -Azienda USL Toscana nord ovest
Livorno, Italy
Actively Recruiting
16
Fondazione IRCCS Istituto Neurologico Carlo Besta
Milan, Italy, 20133
Actively Recruiting
17
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Italy, 20122
Active, Not Recruiting
18
ASST Santi Paolo e Carlo
Milan, Italy, 20153
Actively Recruiting
19
ASST Fatebenefratelli Sacco
Milan, Italy
Active, Not Recruiting
20
Istituto Clinico Città Studi
Milan, Italy
Active, Not Recruiting
21
Policlinico di Monza
Monza, Italy, 20900
Actively Recruiting
22
A.R.N.A.S. Ospedali Civico di Palermo
Palermo, Italy, 90127
Actively Recruiting
23
Azienda Ospedaliero Universitaria di Parma
Parma, Italy
Active, Not Recruiting
24
ASL Roma 1
Roma, Italy, 00135
Actively Recruiting
25
Fondazione Policlinico Universitario Gemelli di Roma
Roma, Italy, 00168
Actively Recruiting
26
IRCCS Istituto Clinico Humanitas
Rozzano, Italy, 20089
Active, Not Recruiting
27
Azienda Sanitaria Universitaria Friuli Centrale di Udine
Udine, Italy, 33100
Actively Recruiting
Loading map...
Research Team
P
Paolo Ferroli, MD
M
Morgan A Broggi, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Published Research Related To This Trial
Cerebral vascular accidents in patients over the age of 60. II. Prognosis.
J RANKIN
https://pubmed.ncbi.nlm.nih.gov/13432835A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.
M E Charlson, P Pompei, K L Ales...
https://pubmed.ncbi.nlm.nih.gov/3558716National Institute of Neurological Disorders and Stroke Common Data Element Project - approach and methods.
Stacie T Grinnon, Kristy Miller, John R Marler...
https://pubmed.ncbi.nlm.nih.gov/22371630Quality of life in patients with intracranial gliomas: the impact of modern image-guided surgery.
Asgeir S Jakola, Geirmund Unsgård, Ole Solheim
https://pubmed.ncbi.nlm.nih.gov/21314270Accuracy of operating neurosurgeons' prediction of functional levels after intracranial tumor surgery.
Lisa Millgård Sagberg, Christina Drewes, Asgeir S Jakola...
https://pubmed.ncbi.nlm.nih.gov/27315026Patient-Reported Outcomes (PROs) and Patient-Reported Outcome Measures (PROMs).
Theresa Weldring, Sheree M S Smith
https://pubmed.ncbi.nlm.nih.gov/25114561Preoperative Frailty Score for 30-Day Morbidity and Mortality After Cranial Neurosurgery.
Samuel B Tomlinson, Keaton Piper, Kristopher T Kimmell...
https://pubmed.ncbi.nlm.nih.gov/28736345Evidence for the use of preoperative risk assessment scores in elective cranial neurosurgery: a systematic review of the literature.
Elina Reponen, Hanna Tuominen, Miikka Korja
https://pubmed.ncbi.nlm.nih.gov/25046789