Diagnosis and Treatment of Interstitial Cystitis/Bladder Pain Syndrome.
J Quentin Clemens, Deborah R Erickson, Norma P Varela...
https://pubmed.ncbi.nlm.nih.gov/35536143Actively Recruiting
Led by Walter Reed National Military Medical Center · Updated on 2026-04-30
5
Participants Needed
1
Research Sites
N/A
Total Duration
Bladder Pain Syndrome (BPS) is a complex chronic pain condition mainly affecting women, characterized by bladder pain, pressure, and discomfort alongside urinary urgency and frequency. This study aims to explore whether using electrical micro-current directed at the superior hypogastric plexus, a nerve group involved in pelvic pain, can reduce pain in women aged 18 and older diagnosed with BPS. Current treatments vary and are not universally effective, so this research investigates a novel approach called pulsed radiofrequency ablation (pRFA) for pain relief. Participants will undergo a one-time procedure where two needles are inserted near the spine to deliver brief bursts of electrical micro-current to the target nerve, targeting pain pathways. The procedure includes local anesthesia and fluoroscopic guidance. After treatment, participants will have follow-up visits at 1, 3, and 6 months to assess pain, mood, sexual function, and bladder irritation symptoms. The study focuses on evaluating changes in pain scores and other relevant symptoms over six months. Participants will be evaluated at the start and during follow-up visits in a chronic pain clinic setting. Assessments include pain severity using the Visual Analog Scale (VAS), bladder symptom indices, urinary frequency, mood questionnaires, and patient-reported impressions of symptom severity and improvement. Researchers will closely monitor these measures to understand the effects of the treatment. The total participation time is six months from the initial procedure, with detailed symptom tracking throughout the study period.
CONDITIONS
New Approaches to Nerve Stimulation Therapy for Bladder Pain Syndrome
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single treatment session
Participants receive pulsed radiofrequency ablation targeting the superior hypogastric plexus to treat bladder pain syndrome.
1 treatment visit (in-person)
Duration - 6 months
Participants are monitored for pain and symptom relief with assessments of pain, urinary symptoms, mood, and overall satisfaction.
3 follow-up visits at 1, 3, and 6 months (in-person)
Total: 1 location
1
Walter Reed National Military Medical Center
Bethesda, Maryland, United States, 20814
Actively Recruiting
E
Eli Medvescek, MD
S
Sara Wilson, MD
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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