Actively Recruiting

Age: 18Years - 130Years
All Genders
NCT06465810

Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

Led by AstraZeneca · Updated on 2026-05-05

1850

Participants Needed

60

Research Sites

391 weeks

Total Duration

On this page

Sponsors

A

AstraZeneca

Lead Sponsor

I

ICON plc

Collaborating Sponsor

AI-Summary

What this Trial Is About

The MaesTTRo study aims to enroll a global cohort of patients with transthyretin (ATTR) amyloidosis to longitudinally observe the natural course of the disease and describe real-world treatment patterns and outcomes. In addition, information on the effectiveness of ATTR amyloidosis treatments, including eplontersen, which is a ligand-conjugated antisense oligonucleotide gene silencing treatment targeting activity against both the mutant and wild-type TTR protein, will be collected.

CONDITIONS

Official Title

Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

Who Can Participate

Age: 18Years - 130Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patient willing and able to provide written informed consent to participate in the study
  • Confirmed diagnosis of amyloid transthyretin (ATTR) amyloidosis
  • Aged 18 years or older at the time of signing the informed consent
  • Patient willing and able to participate in collection of electronic patient reported outcomes (PROs)
Not Eligible

You will not qualify if you...

  • Concurrent participation in any interventional trial for ATTR amyloidosis
  • Involvement in the planning and/or conduct of the current study
  • Patients with evidence of primary or light chain amyloidosis (AL) or serum protein A amyloidosis (AA)
  • Asymptomatic patients with ATTR amyloidosis and asymptomatic ATTR mutation carriers

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 60 locations

1

Research Site

La Jolla, California, United States, 92037

Actively Recruiting

2

Research Site

Los Angeles, California, United States, 90095

Actively Recruiting

3

Research Site

San Francisco, California, United States, 94025

Actively Recruiting

4

Research Site

San Francisco, California, United States, 94143

Actively Recruiting

5

Research Site

New Haven, Connecticut, United States, 06510

Actively Recruiting

6

Research Site

Washington D.C., District of Columbia, United States, 20010

Actively Recruiting

7

Research Site

Chicago, Illinois, United States, 60637

Actively Recruiting

8

Research Site

Indianapolis, Indiana, United States, 06200

Actively Recruiting

9

Research Site

Boston, Massachusetts, United States, 02111

Actively Recruiting

10

Research Site

Boston, Massachusetts, United States, 02114

Not Yet Recruiting

11

Research Site

Boston, Massachusetts, United States, 02115

Actively Recruiting

12

Research Site

Rochester, Minnesota, United States, 55905

Actively Recruiting

13

Research Site

Kansas City, Missouri, United States, 64111

Actively Recruiting

14

Research Site

St Louis, Missouri, United States, 63110

Actively Recruiting

15

Research Site

New Brunswick, New Jersey, United States, 08901

Actively Recruiting

16

Research Site

Manhasset, New York, United States, 11030

Actively Recruiting

17

Research Site

New York, New York, United States, 10027

Actively Recruiting

18

Research Site

New York, New York, United States, 10029

Actively Recruiting

19

Research Site

Durham, North Carolina, United States, 27710

Actively Recruiting

20

Research Site

Danville, Pennsylvania, United States, 17822

Actively Recruiting

21

Research Site

Philadelphia, Pennsylvania, United States, 19104

Actively Recruiting

22

Research Site

Philadelphia, Pennsylvania, United States, 19107

Actively Recruiting

23

Research Site

Greenville, South Carolina, United States, 29607

Actively Recruiting

24

Research Site

Germantown, Tennessee, United States, 38138

Actively Recruiting

25

Research Site

Nashville, Tennessee, United States, 037214

Actively Recruiting

26

Research Site

Dallas, Texas, United States, 75246

Actively Recruiting

27

Research Site

Richmond, Virginia, United States, 23298

Actively Recruiting

28

Research Site

Seattle, Washington, United States, 98915

Actively Recruiting

29

Research Site

Milwaukee, Wisconsin, United States, 53226

Actively Recruiting

30

Research Site

Vancouver, British Columbia, Canada, V5Z 1M9

Actively Recruiting

31

Research Site

Vancouver, British Columbia, Canada, V6Z 1Y6

Actively Recruiting

32

Research Site

Halifax, Nova Scotia, Canada, B3RIV9

Actively Recruiting

33

Research Site

London, Ontario, Canada, N6A 5A5

Actively Recruiting

34

Research Site

Toronto, Ontario, Canada, M2J 4W8

Actively Recruiting

35

Research Site

Rimouski, Quebec, Canada, G5L 5T1

Not Yet Recruiting

36

Research Site

Beijing, Beijing Municipality, China, 100034

Not Yet Recruiting

37

Research Site

Beijing, Beijing Municipality, China, 100191

Not Yet Recruiting

38

Research Site

Beijing, Beijing Municipality, China, 100730

Actively Recruiting

39

Research Site

Changsha, Hunan, China, 410013

Not Yet Recruiting

40

Research Site

Shanghai, Shanghai Municipality, China, 200040

Actively Recruiting

41

Research Site

Hebei Sheng, Shijiazhuang, China, 050000

Not Yet Recruiting

42

Research Site

Shaanxi, Xi'An, China, 710061

Actively Recruiting

43

Research Site

Würzburg, Bavaria, Germany, DE-97072

Not Yet Recruiting

44

Research Site

Frankfurt am Main, Hesse, Germany, 60590

Actively Recruiting

45

Research Site

Hanover, Lower Saxony, Germany, 30625

Actively Recruiting

46

Research Site

Aachen, North Rhine-Westphalia, Germany, 52074

Actively Recruiting

47

Research Site

Cologne, North Rhine-Westphalia, Germany, 50937

Actively Recruiting

48

Research Site

Mainz, Rhineland-Palatinate, Germany, 55131

Actively Recruiting

49

Research Site

Homburg, Saarland, Germany, 66421

Actively Recruiting

50

Research Site

Berlin, Germany, 10117

Actively Recruiting

51

Research Site

Huelva, Andalusia, Spain, 21005

Actively Recruiting

52

Research Site

Cataluna, Barcelona, Spain, 08907

Not Yet Recruiting

53

Research Site

Bilbao, Basque Country, Spain, 48013

Actively Recruiting

54

Research Site

Las Palmas de Gran Canaria, Canary Islands, Spain, 35010

Actively Recruiting

55

Research Site

Salamanca, Castille and León, Spain, 37007

Actively Recruiting

56

Research Site

Barcelona, Catalu A, Spain, 08035

Actively Recruiting

57

Research Site

Islas Baleares, Palma de Mallorca, Spain, 07198

Actively Recruiting

58

Research Site

Birmingham, West Midlands, United Kingdom, B15 2GW

Actively Recruiting

59

Research Site

Glasgow, United Kingdom, G51 4TF

Actively Recruiting

60

Research Site

London, United Kingdom, NW3 2QG

Actively Recruiting

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Research Team

A

AstraZeneca Clinical Study Information Center

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

3

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Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis | DecenTrialz