Actively Recruiting
Norwegian Spontaneous Coronary Artery Dissection Study (NOR-SCAD Study)
Led by Oslo University Hospital · Updated on 2026-01-05
300
Participants Needed
3
Research Sites
N/A
Total Duration
On this page
Sponsors
O
Oslo University Hospital
Lead Sponsor
U
University Hospital, Akershus
Collaborating Sponsor
AI-Summary
What this Trial Is About
The Norwegian Spontaneous Coronary Artery Dissection Study (NOR-SCAD) is a national, multicenter prospective observational study focused on people aged 18 years or older who are hospitalized with spontaneous coronary artery dissection (SCAD). Researchers are investigating the risk factors, complications, and major adverse cardiac events (MACE) that may occur within the first year after SCAD. The study also aims to evaluate the usefulness of coronary CT angiography (CTA) in diagnosis and follow-up. Participants are enrolled during their initial hospital stay where imaging and blood samples are collected. Follow-up includes scheduled visits at 8 weeks for a control CT scan, at 12 weeks for a thorough physical exam with cardiac assessments, blood tests, and a cardiopulmonary exercise test (CPET). A final phone call at 52 weeks checks for clinical events and collects additional information. During the study, participants undergo coronary CTA scans, cardiac exams, blood sampling, genetic testing, and structured questionnaires to assess quality of life. Researchers track major cardiac events and changes seen in imaging over time. The total follow-up lasts 52 weeks, with the main outcome being the occurrence of major adverse cardiac events during this period.
CONDITIONS
Brief Title
Norwegian Spontaneous Coronary Artery Dissection Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Diagnosed with spontaneous coronary artery dissection (SCAD)
You will not qualify if you...
- Severe kidney failure
- Severe allergic reaction to contrast dye
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 week
Participants undergo acute hospitalization with CT imaging and blood sample collection to confirm SCAD diagnosis and assess initial condition.
1 visit (in-person)
Duration - 12 weeks
Participants receive follow-up coronary CT angiography (CTA) and comprehensive physical and cardiac examinations including blood samples and cardiopulmonary exercise testing to monitor recovery and cardiac health.
2 visits (in-person) at Week 8 and Week 12
Duration - Approximately 40 weeks
Participants are monitored through a final follow-up phone call to assess clinical events and quality of life outcomes one year after SCAD diagnosis.
1 follow-up phone call at Week 52
Trial Site Locations
Total: 3 locations
1
Haukeland University Hospital
Bergen, Norway
Actively Recruiting
2
Akershus University Hospital
Oslo, Norway
Actively Recruiting
3
Rikshospitalet, Oslo University Hospital
Oslo, Norway
Actively Recruiting
Research Team
A
Anna Louise Astad Sørlie, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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