Canadian spontaneous coronary artery dissection cohort study: in-hospital and 30-day outcomes.
Jacqueline Saw, Andrew Starovoytov, Karin Humphries...
https://pubmed.ncbi.nlm.nih.gov/30698711Actively Recruiting
Age: 18Years +
All Genders
ID04906356
Canadian Spontaneous Coronary Artery Dissection (SCAD) Study and Genetic Sub-study (Prospective, Observational Registry With 10 Year Follow-up)
Led by Cardiology Research UBC · Updated on 2021-05-28
3000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
C
Cardiology Research UBC
Lead Sponsor
J
John GB Mancini, MD
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are conducting a large, international observational study called the Canadian SCAD Study to understand spontaneous coronary artery dissection (SCAD), a condition that mainly affects young women without usual heart risk factors and can lead to heart attacks or death. SCAD is often misdiagnosed due to limits of current tests, so this study aims to better understand the condition's natural history, predisposing factors, and treatments over time. The study will enroll about 3,000 patients diagnosed with SCAD from multiple centers in Canada, the United States, and other countries. Participants will be followed for up to 10 years to track cardiovascular events. A genetic sub-study involves a one-time saliva sample collection. The study uses electronic consent for wide geographic participation and collects detailed health history and investigations related to SCAD. Participants will undergo detailed baseline assessments, including history and diagnostic testing, and will be monitored regularly for heart-related outcomes both during hospitalization and over the long term. The main outcomes measured include cardiovascular events during hospital stay and up to 10 years later. Secondary outcomes include arterial healing and success of coronary procedures. This long-term follow-up aims to improve knowledge of SCAD and guide future treatment trials.
CONDITIONS
Brief Title
Canadian SCAD Study
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Patients admitted with acute coronary syndrome (STEMI, NSTEMI, or unstable angina)
- Documented spontaneous coronary artery dissection on coronary angiogram or related imaging (OCT or IVUS)
You will not qualify if you...
- Patients with SCAD attributed to atherosclerotic coronary artery disease with stenosis 50% or greater
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Diagnostic Evaluation
Duration - During hospital admission
Participants undergo coronary angiogram or related imaging to document spontaneous coronary artery dissection (SCAD).
1 hospital admission visit (in-person)
Surveillance
Duration - Up to 10 years
Participants are followed long-term to monitor cardiovascular events and arterial healing after SCAD.
Periodic follow-up visits over 10 years
Trial Site Locations
Total: 1 location
1
Vancouver General Hospital
Vancouver, British Columbia, Canada, V5Z1M9
Actively Recruiting
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Research Team
A
Andrew Starovoytov, MD
J
Johandra Argote Parolis, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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