What is this study trying to find out about spontaneous coronary artery dissection (SCAD)?

This study aims to learn more about SCAD, a condition affecting the heart arteries that can cause serious events like heart attacks. Researchers want to understand the natural history, risk factors, and treatment approaches for SCAD over time. The study is led by Cardiology Research UBC and involves multiple centers internationally.

Who may be eligible for this spontaneous coronary artery dissection clinical trial?

Adults aged 18 years or older who were admitted with acute coronary syndrome and have a confirmed diagnosis of SCAD may be eligible. There is no gender restriction. Patients with significant atherosclerotic coronary artery disease are excluded. Please review eligibility criteria for more details.

Is there any cost to participate in this spontaneous coronary artery dissection clinical trial?

Study-related care, including all procedures and follow-up, is provided at no cost. However, personal travel and other expenses may vary and are not guaranteed to be covered.

Actively Recruiting

Age: 18Years +

All Genders

ID04906356

Canadian Study on Spontaneous Coronary Artery Dissection SCAD and Genetic Research with 10-Year Follow-up

Led by Cardiology Research UBC · Updated on 2021-05-28

3000

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Researchers are conducting a large, international observational study called the Canadian SCAD Study to understand spontaneous coronary artery dissection SCAD, a condition that mainly affects young women without usual heart risk factors and can lead to heart attacks or death. SCAD is often misdiagnosed due to limits of current tests, so this study aims to better understand the conditions natural history, predisposing factors, and treatments over time. The study will enroll about 3,000 patients diagnosed with SCAD from multiple centers in Canada, the United States, and other countries. Participants will be followed for up to 10 years to track cardiovascular events. A genetic sub-study involves a one-time saliva sample collection. The study uses electronic consent for wide geographic participation and collects detailed health history and investigations related to SCAD. Participants will undergo detailed baseline assessments, including history and diagnostic testing, and will be monitored regularly for heart-related outcomes both during hospitalization and over the long term. The main outcomes measured include cardiovascular events during hospital stay and up to 10 years later. Secondary outcomes include arterial healing and success of coronary procedures. This long-term follow-up aims to improve knowledge of SCAD and guide future treatment trials.

CONDITIONS

Brief Title

Canadian SCAD Study

Who Can Participate

Age: 18Years +

All Genders

Eligibility Criteria

You may qualify if you...

Patients admitted with acute coronary syndrome (STEMI, NSTEMI, or unstable angina)
Documented spontaneous coronary artery dissection on coronary angiogram or related imaging (OCT or IVUS)

You will not qualify if you...

Patients with SCAD attributed to atherosclerotic coronary artery disease with stenosis 50% or greater

Research Team

Andrew Starovoytov, MD

Johandra Argote Parolis, MD

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