Different remifentanil doses in rapid sequence anesthesia induction: BIS monitoring and intubation conditions.
Zekeriyya Alanoğlu, Sinem Tolu, Saban Yalçın...
https://pubmed.ncbi.nlm.nih.gov/23468262Actively Recruiting
Age: 18Years +
All Genders
ID07588165
Nociception Assessment During Rapid Sequence Induction: A Prospective Observational Study of Practices and Complications - The NARSI Study
Led by Centre Hospitalier Princesse Grace · Updated on 2026-05-27
150
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating pain responses during rapid sequence induction (RSI), a common anesthesia technique used to reduce the risk of aspiration in patients undergoing tracheal intubation. This observational study aims to describe pain levels measured by the Analgesia Nociception Index (ANI) during RSI and to explore early complications such as desaturation, low blood pressure, and regurgitation, as well as factors linked to pain and complications. The study will analyze 150 patients undergoing RSI in a visceral surgery operating room. Participants receive standard RSI care following French anesthesia guidelines, with anesthesiologists choosing induction drugs such as hypnotics, opioids, and neuromuscular blockers based on routine practice. During the procedure, additional non-invasive electrodes placed on the chest monitor ANI to assess pain responses. The study records various clinical data including heart rate, blood pressure, oxygen levels, intubation devices used, and postoperative sore throat occurrence. Throughout the study, patients are monitored for 5 minutes following RSI for changes in ANI and hemodynamic parameters. Data on early complications and intubation success are collected, alongside patient characteristics and medication use. Follow-up continues for 24 hours to assess sore throat presence. The study involves no extra examinations beyond standard care and aims to provide detailed pain and complication profiles during RSI.
CONDITIONS
Brief Title
Pain Assessment During Rapid Sequence Induction
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Age �3A 18 years
- Patient requiring tracheal intubation after rapid sequence induction in the visceral surgery operating room
- Pain monitoring by Analgesia Nociception Index (ANI) as part of general anesthesia
You will not qualify if you...
- Patient with atrial fibrillation at the time of intubation following rapid sequence induction
- Patient on long-term beta-blocker therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Monitoring
Duration - 5 minutes post-induction
Participants undergoing rapid sequence induction are monitored using standard anesthesia care with additional non-invasive Analgesia Nociception Index (ANI) monitoring via cutaneous electrodes during the first 5 minutes after induction.
1 in-person monitoring during anesthesia induction
Long-term Monitoring
Duration - 24 hours post-intubation
Participants are observed for postoperative complications including the presence of sore throat up to 24 hours after intubation.
1 follow-up assessment within 24 hours after intubation
Trial Site Locations
Total: 1 location
1
Centre Hospitalier Princesse Grace
Monaco, Monaco, 98000
Actively Recruiting
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Research Team
R
Remy WIDEHEM
C
Celine DUGOURD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
Bolus dose remifentanil for control of haemodynamic response to tracheal intubation during rapid sequence induction of anaesthesia.
R O'Hare, D McAtamney, R K Mirakhur...
https://pubmed.ncbi.nlm.nih.gov/10365011Efficacy and safety of remifentanil in a rapid sequence induction in elderly patients: A three-arm parallel, double blind, randomised controlled trial.
Arnaud Chaumeron, Jeremie Castanie, Louis Philippe Fortier...
https://pubmed.ncbi.nlm.nih.gov/31614244Assessing pain in paralyzed critically ill patients receiving neuromuscular blocking agents: A monocenter prospective cohort.
Jules Voeltzel, Océane Garnier, Albert Prades...
https://pubmed.ncbi.nlm.nih.gov/38710326Measurement of the nociceptive balance by Analgesia Nociception Index and Surgical Pleth Index during sevoflurane-remifentanil anesthesia.
M Gruenewald, J Herz, T Schoenherr...
https://pubmed.ncbi.nlm.nih.gov/25032676Validation of Innovative Techniques for Monitoring Nociception during General Anesthesia: A Clinical Study Using Tetanic and Intracutaneous Electrical Stimulation.
Sandra Funcke, Sven Sauerlaender, Hans O Pinnschmidt...
https://pubmed.ncbi.nlm.nih.gov/28489614Post-induction hypotension during rapid sequence intubation in the operating room: A post hoc analysis of the randomized controlled REMICRUSH trial.
Nicolas Grillot, Victoire Gonzalez, Romain Deransy...
https://pubmed.ncbi.nlm.nih.gov/40086728Effect of Remifentanil vs Neuromuscular Blockers During Rapid Sequence Intubation on Successful Intubation Without Major Complications Among Patients at Risk of Aspiration: A Randomized Clinical Trial.
Nicolas Grillot, Gilles Lebuffe, Olivier Huet...
https://pubmed.ncbi.nlm.nih.gov/36594947Current practice of rapid sequence induction of anaesthesia in the UK - a national survey.
A Sajayan, J Wicker, N Ungureanu...
https://pubmed.ncbi.nlm.nih.gov/26917599Ketamine Versus Etomidate for Rapid Sequence Intubation: A Systematic Review and Meta-Analysis of Randomized Trials.
Alisha Greer, Mark Hewitt, Parsa T Khazaneh...
https://pubmed.ncbi.nlm.nih.gov/39570063