Actively Recruiting
Phonological Constraints on Language Development in Individuals With Williams Syndrome
Led by Centre Hospitalier Universitaire, Amiens · Updated on 2025-12-16
130
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Williams syndrome (WS) is a neurodevelopmental disorder marked by mild to moderate intellectual disability and a wide range of cognitive features. This research aims to explore the connection between the unique social behavior, strong language skills, and sensitivity to sounds (hyperacusis) in individuals with WS. The study also compares these findings with individuals who have Down syndrome (DS), known for difficulties with short-term phonological memory and language abilities, to better understand language development in WS. Participants will undergo physiological assessments using an EEG-NIRS protocol and complete questionnaires. These tests will be conducted individually in a quiet setting, lasting about 120 minutes per participant. The study includes groups of patients with WS, DS, typically developing children and adolescents aged 6 to 17, and healthy adults aged 20 to 60. During the study, researchers will measure participants' questionnaire scores over two years to assess language characteristics and the influence of hyperacusis on these scores. The evaluations will compare the performance of WS individuals to those with DS and typical development, focusing on phonological short-term memory and language skills. The total participation duration is planned for two years, with repeated assessments to monitor changes.
CONDITIONS
Brief Title
Phonological Constraints on Language Development in Individuals With Williams Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- For Williams syndrome and Down syndrome: genetic diagnosis and aged between 6 and 17 years old
- For typical participants: children, adolescents, or young adults aged 6 to 17 years
- Adults aged between 20 and 60 years
You will not qualify if you...
- Autistic associated disorders
- West syndrome
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 2 hours
Participants complete EEG-NIRS protocol and a questionnaire individually in a quiet room at the research center.
1 visit (in-person)
Duration - 2 years
Participants are observed for 2 years to assess questionnaire scores and impact of hyperacusis.
Follow-up assessments may occur during this period
Trial Site Locations
Total: 1 location
1
CHU Amiens
Amiens, France, 80054
Actively Recruiting
Research Team
F
Fabrice Wallois, Pr
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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