Actively Recruiting
Phonological Constraints on Language Development in Individuals With Williams Syndrome
Led by Centre Hospitalier Universitaire, Amiens · Updated on 2025-12-16
130
Participants Needed
1
Research Sites
103 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Williams syndrome (WS) is a neurodevelopmental disease characterized by mild to moderate intellectual disability and an extremely heterogeneous cognitive profile. Research has outlined two main features of WS: an atypical social behavior associated with surprising language abilities, and a hyperacusis. The purpose of this project is to investigate the relationships between both these abilities, and particularly the role of the hyperacusis on language abilities. The hyperacusis would be crucial in developing language skills: the apparent strength in the verbal domain could rely on Phonological Short Term Memory (PSTM) more in individuals with WS than in typically developing individuals. In addition, the investigators will compare individuals with WS to individuals with Down syndrome (DS): DS is often associated to strong limitations in the PSTM with poor language abilities. To this end, the investigators will use a highly innovative approach including physiological assessments (EEG-NIRS protocol) and questionnaires. The performance of people with WS will be compared to those of participants with DS and TD participants of same DA and cognitive assessments.
CONDITIONS
Official Title
Phonological Constraints on Language Development in Individuals With Williams Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- For Williams syndrome and Down syndrome: genetic diagnosis and aged between 6 and 17 years old
- For typical participants: any child, adolescent, or young adult of the same developmental or chronological age between 6 and 17 years old
- Adult group between 20 and 60 years old
You will not qualify if you...
- Autistic Associated Disorders
- West syndrome
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
CHU Amiens
Amiens, France, 80054
Actively Recruiting
Research Team
F
Fabrice Wallois, Pr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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